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Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression
Zeta-associated protein-70 (ZAP70) expression measured by flow cytometry has been proposed as a surrogate marker of the somatic mutation status of the immunoglobulin heavy chain variable region genes in chronic lymphocytic leukemia. However, attempts to implement this approach in clinical flow cytom...
Autores principales: | Admirand, Joan H., Knoblock, Ronald J., Coombes, Kevin R., Tam, Constantine, Schlette, Ellen J., Keating, Michael J., Luthra, Rajyalakshmi, Medeiros, L. Jeffrey, Abruzzo, Lynne V. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966512/ https://www.ncbi.nlm.nih.gov/pubmed/20657554 http://dx.doi.org/10.1038/modpathol.2010.131 |
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