SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ?
Several studies suggest that a low cholesterol concentration is associated with depression. The authors sought to determine whether an association exists between serum lipid concentrations and depression. 28 drug-naive patients of major depression diagnosed according to DSMlll- R criteria were inclu...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
1998
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966595/ https://www.ncbi.nlm.nih.gov/pubmed/21494476 |
_version_ | 1782189599398821888 |
---|---|
author | Khalid, Abdul Lal, Narottam Trivedi, J.K. Dalal, P.K. Asthana, O.P. Srivastava, J.S. Akhtar, Asif |
author_facet | Khalid, Abdul Lal, Narottam Trivedi, J.K. Dalal, P.K. Asthana, O.P. Srivastava, J.S. Akhtar, Asif |
author_sort | Khalid, Abdul |
collection | PubMed |
description | Several studies suggest that a low cholesterol concentration is associated with depression. The authors sought to determine whether an association exists between serum lipid concentrations and depression. 28 drug-naive patients of major depression diagnosed according to DSMlll- R criteria were included in the study and severity of depression was measured on Hamilton Rating Scale for Depression. Suicidal intent was assessed on Suicidal Intent Questionnaire. 28 normal healthy controls were selected and matched for age, sex and body-mass index with the depressives. Serum lipid estimations were done in each subject after 12 hours overnight fasting. The main finding of the study is that total serum cholesterol, serum triglycerides and serum LDL cholesterol are decreased while serum HDL cholesterol is increased in depression and these changes were more marked in depressed subjects with definite suicidal intent. On regression analysis, total serum cholesterol was the most important predictive variable of the severity of depression. |
format | Text |
id | pubmed-2966595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29665952011-04-14 SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ? Khalid, Abdul Lal, Narottam Trivedi, J.K. Dalal, P.K. Asthana, O.P. Srivastava, J.S. Akhtar, Asif Indian J Psychiatry Original Article Several studies suggest that a low cholesterol concentration is associated with depression. The authors sought to determine whether an association exists between serum lipid concentrations and depression. 28 drug-naive patients of major depression diagnosed according to DSMlll- R criteria were included in the study and severity of depression was measured on Hamilton Rating Scale for Depression. Suicidal intent was assessed on Suicidal Intent Questionnaire. 28 normal healthy controls were selected and matched for age, sex and body-mass index with the depressives. Serum lipid estimations were done in each subject after 12 hours overnight fasting. The main finding of the study is that total serum cholesterol, serum triglycerides and serum LDL cholesterol are decreased while serum HDL cholesterol is increased in depression and these changes were more marked in depressed subjects with definite suicidal intent. On regression analysis, total serum cholesterol was the most important predictive variable of the severity of depression. Medknow Publications 1998 /pmc/articles/PMC2966595/ /pubmed/21494476 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khalid, Abdul Lal, Narottam Trivedi, J.K. Dalal, P.K. Asthana, O.P. Srivastava, J.S. Akhtar, Asif SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ? |
title | SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ? |
title_full | SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ? |
title_fullStr | SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ? |
title_full_unstemmed | SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ? |
title_short | SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ? |
title_sort | serum lipids : new biological markers in depression ? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966595/ https://www.ncbi.nlm.nih.gov/pubmed/21494476 |
work_keys_str_mv | AT khalidabdul serumlipidsnewbiologicalmarkersindepression AT lalnarottam serumlipidsnewbiologicalmarkersindepression AT trivedijk serumlipidsnewbiologicalmarkersindepression AT dalalpk serumlipidsnewbiologicalmarkersindepression AT asthanaop serumlipidsnewbiologicalmarkersindepression AT srivastavajs serumlipidsnewbiologicalmarkersindepression AT akhtarasif serumlipidsnewbiologicalmarkersindepression |