SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ?

Several studies suggest that a low cholesterol concentration is associated with depression. The authors sought to determine whether an association exists between serum lipid concentrations and depression. 28 drug-naive patients of major depression diagnosed according to DSMlll- R criteria were inclu...

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Autores principales: Khalid, Abdul, Lal, Narottam, Trivedi, J.K., Dalal, P.K., Asthana, O.P., Srivastava, J.S., Akhtar, Asif
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966595/
https://www.ncbi.nlm.nih.gov/pubmed/21494476
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author Khalid, Abdul
Lal, Narottam
Trivedi, J.K.
Dalal, P.K.
Asthana, O.P.
Srivastava, J.S.
Akhtar, Asif
author_facet Khalid, Abdul
Lal, Narottam
Trivedi, J.K.
Dalal, P.K.
Asthana, O.P.
Srivastava, J.S.
Akhtar, Asif
author_sort Khalid, Abdul
collection PubMed
description Several studies suggest that a low cholesterol concentration is associated with depression. The authors sought to determine whether an association exists between serum lipid concentrations and depression. 28 drug-naive patients of major depression diagnosed according to DSMlll- R criteria were included in the study and severity of depression was measured on Hamilton Rating Scale for Depression. Suicidal intent was assessed on Suicidal Intent Questionnaire. 28 normal healthy controls were selected and matched for age, sex and body-mass index with the depressives. Serum lipid estimations were done in each subject after 12 hours overnight fasting. The main finding of the study is that total serum cholesterol, serum triglycerides and serum LDL cholesterol are decreased while serum HDL cholesterol is increased in depression and these changes were more marked in depressed subjects with definite suicidal intent. On regression analysis, total serum cholesterol was the most important predictive variable of the severity of depression.
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spelling pubmed-29665952011-04-14 SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ? Khalid, Abdul Lal, Narottam Trivedi, J.K. Dalal, P.K. Asthana, O.P. Srivastava, J.S. Akhtar, Asif Indian J Psychiatry Original Article Several studies suggest that a low cholesterol concentration is associated with depression. The authors sought to determine whether an association exists between serum lipid concentrations and depression. 28 drug-naive patients of major depression diagnosed according to DSMlll- R criteria were included in the study and severity of depression was measured on Hamilton Rating Scale for Depression. Suicidal intent was assessed on Suicidal Intent Questionnaire. 28 normal healthy controls were selected and matched for age, sex and body-mass index with the depressives. Serum lipid estimations were done in each subject after 12 hours overnight fasting. The main finding of the study is that total serum cholesterol, serum triglycerides and serum LDL cholesterol are decreased while serum HDL cholesterol is increased in depression and these changes were more marked in depressed subjects with definite suicidal intent. On regression analysis, total serum cholesterol was the most important predictive variable of the severity of depression. Medknow Publications 1998 /pmc/articles/PMC2966595/ /pubmed/21494476 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khalid, Abdul
Lal, Narottam
Trivedi, J.K.
Dalal, P.K.
Asthana, O.P.
Srivastava, J.S.
Akhtar, Asif
SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ?
title SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ?
title_full SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ?
title_fullStr SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ?
title_full_unstemmed SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ?
title_short SERUM LIPIDS : NEW BIOLOGICAL MARKERS IN DEPRESSION ?
title_sort serum lipids : new biological markers in depression ?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966595/
https://www.ncbi.nlm.nih.gov/pubmed/21494476
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