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The impact of CYP2D6-predicted phenotype on tamoxifen treatment outcome in patients with metastatic breast cancer

BACKGROUND: Cytochrome P450 2D6 (CYP2D6) has a crucial role in the metabolic conversion of tamoxifen into the active metabolite endoxifen. In this cohort study, the effect of CYP2D6-predicted phenotype, defined as the combined effect of CYP2D6 genetic variation and concomitant use of CYP2D6-inhibiti...

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Detalles Bibliográficos
Autores principales:	Lammers, L A, Mathijssen, R H J, van Gelder, T, Bijl, M J, de Graan, A-J M, Seynaeve, C, van Fessem, M A, Berns, E M, Vulto, A G, van Schaik, R H N
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966615/ https://www.ncbi.nlm.nih.gov/pubmed/20700120 http://dx.doi.org/10.1038/sj.bjc.6605800

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