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Safety and efficacy of the combination of erlotinib and sirolimus for the treatment of metastatic renal cell carcinoma after failure of sunitinib or sorafenib

BACKGROUND: The mammalian target of rapamycin (mTOR) is an important therapeutic target in the treatment of renal cell carcinoma (RCC). Pre-clinical data indicate that the combined inhibition of both the epidermal growth factor receptor and mTOR results in enhanced anticancer activity. METHODS: All...

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Detalles Bibliográficos
Autores principales:	Flaig, T W, Costa, L J, Gustafson, D L, Breaker, K, Schultz, M K, Crighton, F, Kim, F J, Drabkin, H
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966634/ https://www.ncbi.nlm.nih.gov/pubmed/20823888 http://dx.doi.org/10.1038/sj.bjc.6605868

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