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Pregnancy-Induced Hypertension and Preeclampsia: Levels of Angiogenic Factors in Malaysian Women

Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma l...

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Autores principales: Yelumalai, Suseela, Muniandy, Sekaran, Zawiah Omar, Siti, Qvist, Rajes
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966928/
https://www.ncbi.nlm.nih.gov/pubmed/21103027
http://dx.doi.org/10.3164/jcbn.10-27
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author Yelumalai, Suseela
Muniandy, Sekaran
Zawiah Omar, Siti
Qvist, Rajes
author_facet Yelumalai, Suseela
Muniandy, Sekaran
Zawiah Omar, Siti
Qvist, Rajes
author_sort Yelumalai, Suseela
collection PubMed
description Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma levels of key angiogenic factors in pregnancy as an indicator for the early onset of preeclampsia in pregnancy. Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24–28 weeks (early pregnancy: EP), 32–36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN). The plasma levels of angiogenic factors were determined by ELISA. sFlt-1 levels were elevated in PIH and PE patients as compared to controls. PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls. These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia.
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spelling pubmed-29669282010-11-19 Pregnancy-Induced Hypertension and Preeclampsia: Levels of Angiogenic Factors in Malaysian Women Yelumalai, Suseela Muniandy, Sekaran Zawiah Omar, Siti Qvist, Rajes J Clin Biochem Nutr Original Article Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma levels of key angiogenic factors in pregnancy as an indicator for the early onset of preeclampsia in pregnancy. Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24–28 weeks (early pregnancy: EP), 32–36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN). The plasma levels of angiogenic factors were determined by ELISA. sFlt-1 levels were elevated in PIH and PE patients as compared to controls. PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls. These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia. the Society for Free Radical Research Japan 2010-11 2010-10-29 /pmc/articles/PMC2966928/ /pubmed/21103027 http://dx.doi.org/10.3164/jcbn.10-27 Text en Copyright © 2010 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yelumalai, Suseela
Muniandy, Sekaran
Zawiah Omar, Siti
Qvist, Rajes
Pregnancy-Induced Hypertension and Preeclampsia: Levels of Angiogenic Factors in Malaysian Women
title Pregnancy-Induced Hypertension and Preeclampsia: Levels of Angiogenic Factors in Malaysian Women
title_full Pregnancy-Induced Hypertension and Preeclampsia: Levels of Angiogenic Factors in Malaysian Women
title_fullStr Pregnancy-Induced Hypertension and Preeclampsia: Levels of Angiogenic Factors in Malaysian Women
title_full_unstemmed Pregnancy-Induced Hypertension and Preeclampsia: Levels of Angiogenic Factors in Malaysian Women
title_short Pregnancy-Induced Hypertension and Preeclampsia: Levels of Angiogenic Factors in Malaysian Women
title_sort pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966928/
https://www.ncbi.nlm.nih.gov/pubmed/21103027
http://dx.doi.org/10.3164/jcbn.10-27
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