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How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
Carcinogenesis is an evolutionary process that establishes the ‘hallmarks of cancer’ by natural selection of cell clones that have acquired advantageous heritable characteristics. Evolutionary adaptation has also been proposed as a mechanism that promotes drug resistance during systemic cancer thera...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967073/ https://www.ncbi.nlm.nih.gov/pubmed/20877357 http://dx.doi.org/10.1038/sj.bjc.6605912 |