AN OPEN CLINICAL TRIAL WITH CLOZAPINE IN TREATMENT-RESISTANT SCHIZOPHRENICS

In an open trial, drug-resistant schizophrenics were treated with clozapine for sixteen weeks. The patients were rated on BPRS, PANSS, Side effects scale and Global Impression Scale at weeks 0. 9 and 16. A battery of base-line investigations were done, and hemogram was repeated at weekly intervals....

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Detalles Bibliográficos
Autores principales: Agarwal, A.K., Sharma, Mukul, Srivastava, Shrikant, Mullick, Mrinal, Kumar, Ashutosh
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1997
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967087/
https://www.ncbi.nlm.nih.gov/pubmed/21584048
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author Agarwal, A.K.
Sharma, Mukul
Srivastava, Shrikant
Mullick, Mrinal
Kumar, Ashutosh
author_facet Agarwal, A.K.
Sharma, Mukul
Srivastava, Shrikant
Mullick, Mrinal
Kumar, Ashutosh
author_sort Agarwal, A.K.
collection PubMed
description In an open trial, drug-resistant schizophrenics were treated with clozapine for sixteen weeks. The patients were rated on BPRS, PANSS, Side effects scale and Global Impression Scale at weeks 0. 9 and 16. A battery of base-line investigations were done, and hemogram was repeated at weekly intervals. Of the total 29 patient included. 25 completed the trial. The patients showed significant improvement on both BPRS and PANSS, although the improvement was more in initial weeks than between 9 and 16 weeks. The most common side effects observed were sedation, hypersalivation and tachycardia. Issues of response of clozapine on negative symptoms and a longer duration of the drug therapy are discussed.
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spelling pubmed-29670872011-05-16 AN OPEN CLINICAL TRIAL WITH CLOZAPINE IN TREATMENT-RESISTANT SCHIZOPHRENICS Agarwal, A.K. Sharma, Mukul Srivastava, Shrikant Mullick, Mrinal Kumar, Ashutosh Indian J Psychiatry Original Article In an open trial, drug-resistant schizophrenics were treated with clozapine for sixteen weeks. The patients were rated on BPRS, PANSS, Side effects scale and Global Impression Scale at weeks 0. 9 and 16. A battery of base-line investigations were done, and hemogram was repeated at weekly intervals. Of the total 29 patient included. 25 completed the trial. The patients showed significant improvement on both BPRS and PANSS, although the improvement was more in initial weeks than between 9 and 16 weeks. The most common side effects observed were sedation, hypersalivation and tachycardia. Issues of response of clozapine on negative symptoms and a longer duration of the drug therapy are discussed. Medknow Publications 1997 /pmc/articles/PMC2967087/ /pubmed/21584048 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Agarwal, A.K.
Sharma, Mukul
Srivastava, Shrikant
Mullick, Mrinal
Kumar, Ashutosh
AN OPEN CLINICAL TRIAL WITH CLOZAPINE IN TREATMENT-RESISTANT SCHIZOPHRENICS
title AN OPEN CLINICAL TRIAL WITH CLOZAPINE IN TREATMENT-RESISTANT SCHIZOPHRENICS
title_full AN OPEN CLINICAL TRIAL WITH CLOZAPINE IN TREATMENT-RESISTANT SCHIZOPHRENICS
title_fullStr AN OPEN CLINICAL TRIAL WITH CLOZAPINE IN TREATMENT-RESISTANT SCHIZOPHRENICS
title_full_unstemmed AN OPEN CLINICAL TRIAL WITH CLOZAPINE IN TREATMENT-RESISTANT SCHIZOPHRENICS
title_short AN OPEN CLINICAL TRIAL WITH CLOZAPINE IN TREATMENT-RESISTANT SCHIZOPHRENICS
title_sort open clinical trial with clozapine in treatment-resistant schizophrenics
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967087/
https://www.ncbi.nlm.nih.gov/pubmed/21584048
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