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PP2A(1) Binding, Cell Transducing and Apoptotic Properties of Vpr(77–92): A New Functional Domain of HIV-1 Vpr Proteins

BACKGROUND: The hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that requires a physical interaction of HIV-1 Vpr(...

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Detalles Bibliográficos
Autores principales:	Godet, Angélique N., Guergnon, Julien, Croset, Amélie, Cayla, Xavier, Falanga, Pierre Barthélemy, Colle, Jean-Hervé, Garcia, Alphonse
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967473/ https://www.ncbi.nlm.nih.gov/pubmed/21072166 http://dx.doi.org/10.1371/journal.pone.0013760

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