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Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes

BACKGROUND: Olive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes? METHOD...

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Autores principales: Ebaid, Geovana MX, Seiva, Fábio RF, Rocha, Katiucha KHR, Souza, Gisele A, Novelli, Ethel LB
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967496/
https://www.ncbi.nlm.nih.gov/pubmed/20958965
http://dx.doi.org/10.1186/1475-2891-9-46
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author Ebaid, Geovana MX
Seiva, Fábio RF
Rocha, Katiucha KHR
Souza, Gisele A
Novelli, Ethel LB
author_facet Ebaid, Geovana MX
Seiva, Fábio RF
Rocha, Katiucha KHR
Souza, Gisele A
Novelli, Ethel LB
author_sort Ebaid, Geovana MX
collection PubMed
description BACKGROUND: Olive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes? METHODS: Male Wistar rats were divided into two groups (n = 24/group): (C) receiving standard-chow; (Ob) receiving hypercaloric-chow. After 21 days C and Ob groups were divided into four subgroups (n = 6/group):(C) standard-chow and saline; (C-Olive)standard-chow and olive-oil (3.0 g/kg.day); (C-Oleuropein)standard-chow and oleuropein (0.023 mg/kg/day); (C-Cafeic) standard-chow and cafeic-acid (2.66 mg/kg/day); (Ob)receiving hypercaloric-chow and saline;(Ob-Olive) hypercaloric-chow and olive-oil;(Ob-Oleuropein) hypercaloric-chow and oleuropein;(Ob-Cafeic) hypercaloric-chow and cafeic-acid. Treatments were given twice a week during 21 days. RESULTS: After 42 days, obesity was evidenced in Ob rats from enhanced body-weight, surface-area, and body-mass-index. Energy-expenditure, oxygen consumption(VO(2)) and fat-oxidation were lower in Ob-group than in C. Despite no morphometric changes, Ob-Olive, Ob-Oleuropein and Ob-Cafeic groups had higher VO(2), fat-oxidation, myocardial beta-hydroxyacyl coenzyme-A dehydrogenase and lower respiratory-quotient than Ob. Citrate-synthase was highest in Ob-Olive group. Myocardial lipid-hydroperoxide(LH) and antioxidant enzymes were unaffected by olive-oil and its compounds in obesity condition, whereas LH was lower and total-antioxidant-substances were higher in C-Olive and C-Oleuropein than in C. CONCLUSIONS: The present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions.
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spelling pubmed-29674962010-11-02 Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes Ebaid, Geovana MX Seiva, Fábio RF Rocha, Katiucha KHR Souza, Gisele A Novelli, Ethel LB Nutr J Research BACKGROUND: Olive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes? METHODS: Male Wistar rats were divided into two groups (n = 24/group): (C) receiving standard-chow; (Ob) receiving hypercaloric-chow. After 21 days C and Ob groups were divided into four subgroups (n = 6/group):(C) standard-chow and saline; (C-Olive)standard-chow and olive-oil (3.0 g/kg.day); (C-Oleuropein)standard-chow and oleuropein (0.023 mg/kg/day); (C-Cafeic) standard-chow and cafeic-acid (2.66 mg/kg/day); (Ob)receiving hypercaloric-chow and saline;(Ob-Olive) hypercaloric-chow and olive-oil;(Ob-Oleuropein) hypercaloric-chow and oleuropein;(Ob-Cafeic) hypercaloric-chow and cafeic-acid. Treatments were given twice a week during 21 days. RESULTS: After 42 days, obesity was evidenced in Ob rats from enhanced body-weight, surface-area, and body-mass-index. Energy-expenditure, oxygen consumption(VO(2)) and fat-oxidation were lower in Ob-group than in C. Despite no morphometric changes, Ob-Olive, Ob-Oleuropein and Ob-Cafeic groups had higher VO(2), fat-oxidation, myocardial beta-hydroxyacyl coenzyme-A dehydrogenase and lower respiratory-quotient than Ob. Citrate-synthase was highest in Ob-Olive group. Myocardial lipid-hydroperoxide(LH) and antioxidant enzymes were unaffected by olive-oil and its compounds in obesity condition, whereas LH was lower and total-antioxidant-substances were higher in C-Olive and C-Oleuropein than in C. CONCLUSIONS: The present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions. BioMed Central 2010-10-19 /pmc/articles/PMC2967496/ /pubmed/20958965 http://dx.doi.org/10.1186/1475-2891-9-46 Text en Copyright ©2010 Ebaid et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ebaid, Geovana MX
Seiva, Fábio RF
Rocha, Katiucha KHR
Souza, Gisele A
Novelli, Ethel LB
Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
title Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
title_full Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
title_fullStr Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
title_full_unstemmed Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
title_short Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
title_sort effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967496/
https://www.ncbi.nlm.nih.gov/pubmed/20958965
http://dx.doi.org/10.1186/1475-2891-9-46
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