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Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency

Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We used newly generated MMTV-Cre105Ayn mice to inactivate p53 and/or Rb strictly in the mammary epithelium and to determine recurrent genomic chang...

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Detalles Bibliográficos
Autores principales:	Cheng, Le, Zhou, Zongxiang, Flesken-Nikitin, Andrea, Toshkov, Ilia A., Wang, Wei, Camps, Jordi, Ried, Thomas, Nikitin, Alexander Yu.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967730/ https://www.ncbi.nlm.nih.gov/pubmed/20676140 http://dx.doi.org/10.1038/onc.2010.300

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