1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol

The title compound, C(11)H(12)O(2), is an inter­mediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intra­molecular O—H⋯O hydrogen bond that generates an S(5) ring motif. Inter­molecular O—H⋯O hydrogen b...

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Detalles Bibliográficos
Autores principales: Xu, Jian, Xu, Hao, Quan, Ji-cai, Sha, Fei, Yao, Cheng
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967988/
https://www.ncbi.nlm.nih.gov/pubmed/21581717
http://dx.doi.org/10.1107/S1600536808041068
Descripción
Sumario:The title compound, C(11)H(12)O(2), is an inter­mediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intra­molecular O—H⋯O hydrogen bond that generates an S(5) ring motif. Inter­molecular O—H⋯O hydrogen bonds form centrosymmetric dimers and also link these dimers into chains along the a axis.

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