1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol

The title compound, C(11)H(12)O(2), is an inter­mediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intra­molecular O—H⋯O hydrogen bond that generates an S(5) ring motif. Inter­molecular O—H⋯O hydrogen b...

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Detalles Bibliográficos
Autores principales: Xu, Jian, Xu, Hao, Quan, Ji-cai, Sha, Fei, Yao, Cheng
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967988/
https://www.ncbi.nlm.nih.gov/pubmed/21581717
http://dx.doi.org/10.1107/S1600536808041068
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author Xu, Jian
Xu, Hao
Quan, Ji-cai
Sha, Fei
Yao, Cheng
author_facet Xu, Jian
Xu, Hao
Quan, Ji-cai
Sha, Fei
Yao, Cheng
author_sort Xu, Jian
collection PubMed
description The title compound, C(11)H(12)O(2), is an inter­mediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intra­molecular O—H⋯O hydrogen bond that generates an S(5) ring motif. Inter­molecular O—H⋯O hydrogen bonds form centrosymmetric dimers and also link these dimers into chains along the a axis.
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spelling pubmed-29679882010-12-30 1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol Xu, Jian Xu, Hao Quan, Ji-cai Sha, Fei Yao, Cheng Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(11)H(12)O(2), is an inter­mediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intra­molecular O—H⋯O hydrogen bond that generates an S(5) ring motif. Inter­molecular O—H⋯O hydrogen bonds form centrosymmetric dimers and also link these dimers into chains along the a axis. International Union of Crystallography 2008-12-10 /pmc/articles/PMC2967988/ /pubmed/21581717 http://dx.doi.org/10.1107/S1600536808041068 Text en © Xu et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Xu, Jian
Xu, Hao
Quan, Ji-cai
Sha, Fei
Yao, Cheng
1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol
title 1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol
title_full 1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol
title_fullStr 1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol
title_full_unstemmed 1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol
title_short 1,2,3,4-Tetra­hydro-1,4-methano­naphthalene-2,3-diol
title_sort 1,2,3,4-tetra­hydro-1,4-methano­naphthalene-2,3-diol
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967988/
https://www.ncbi.nlm.nih.gov/pubmed/21581717
http://dx.doi.org/10.1107/S1600536808041068
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AT quanjicai 1234tetrahydro14methanonaphthalene23diol
AT shafei 1234tetrahydro14methanonaphthalene23diol
AT yaocheng 1234tetrahydro14methanonaphthalene23diol

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