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Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats
This study was designed to determine the sequence of events leading to cardiopulmonary effects following acute inhalation of diesel engine exhaust in rats. Rats were exposed for 2 h to diesel engine exhaust (1.9 mg/m(3)), and biological parameters related to antioxidant defense, inflammation, and pr...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968117/ https://www.ncbi.nlm.nih.gov/pubmed/21052503 http://dx.doi.org/10.1155/2010/206057 |
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author | Kooter, Ingeborg M. Gerlofs-Nijland, Miriam E. Boere, A. John F. Leseman, Daan L. A. C. Fokkens, Paul H. B. Spronk, Henri M. H. Frederix, Kim ten Cate, Hugo Knaapen, Ad M. Vreman, Hendrik J. Cassee, Flemming R. |
author_facet | Kooter, Ingeborg M. Gerlofs-Nijland, Miriam E. Boere, A. John F. Leseman, Daan L. A. C. Fokkens, Paul H. B. Spronk, Henri M. H. Frederix, Kim ten Cate, Hugo Knaapen, Ad M. Vreman, Hendrik J. Cassee, Flemming R. |
author_sort | Kooter, Ingeborg M. |
collection | PubMed |
description | This study was designed to determine the sequence of events leading to cardiopulmonary effects following acute inhalation of diesel engine exhaust in rats. Rats were exposed for 2 h to diesel engine exhaust (1.9 mg/m(3)), and biological parameters related to antioxidant defense, inflammation, and procoagulation were examined after 4, 18, 24, 48, and 72 h. This in vivo inhalation study showed a pulmonary anti-oxidant response (an increased activity of the anti-oxidant enzymes glutathione peroxidase and superoxide dismutase and an increase in heme oxygenase-1 protein, heme oxygenase activity, and uric acid) which precedes the inflammatory response (an increase in IL-6 and TNF-α). In addition, increased plasma thrombogenicity and immediate anti-oxidant defense gene expression in aorta tissue shortly after the exposure might suggest direct translocation of diesel engine exhaust components to the vasculature but mediation by other pathways cannot be ruled out. This study therefore shows that different stages in oxidative stress are not only affected by dose increments but are also time dependent. |
format | Text |
id | pubmed-2968117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29681172010-11-04 Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats Kooter, Ingeborg M. Gerlofs-Nijland, Miriam E. Boere, A. John F. Leseman, Daan L. A. C. Fokkens, Paul H. B. Spronk, Henri M. H. Frederix, Kim ten Cate, Hugo Knaapen, Ad M. Vreman, Hendrik J. Cassee, Flemming R. J Toxicol Research Article This study was designed to determine the sequence of events leading to cardiopulmonary effects following acute inhalation of diesel engine exhaust in rats. Rats were exposed for 2 h to diesel engine exhaust (1.9 mg/m(3)), and biological parameters related to antioxidant defense, inflammation, and procoagulation were examined after 4, 18, 24, 48, and 72 h. This in vivo inhalation study showed a pulmonary anti-oxidant response (an increased activity of the anti-oxidant enzymes glutathione peroxidase and superoxide dismutase and an increase in heme oxygenase-1 protein, heme oxygenase activity, and uric acid) which precedes the inflammatory response (an increase in IL-6 and TNF-α). In addition, increased plasma thrombogenicity and immediate anti-oxidant defense gene expression in aorta tissue shortly after the exposure might suggest direct translocation of diesel engine exhaust components to the vasculature but mediation by other pathways cannot be ruled out. This study therefore shows that different stages in oxidative stress are not only affected by dose increments but are also time dependent. Hindawi Publishing Corporation 2010 2010-10-31 /pmc/articles/PMC2968117/ /pubmed/21052503 http://dx.doi.org/10.1155/2010/206057 Text en Copyright © 2010 Ingeborg M. Kooter et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kooter, Ingeborg M. Gerlofs-Nijland, Miriam E. Boere, A. John F. Leseman, Daan L. A. C. Fokkens, Paul H. B. Spronk, Henri M. H. Frederix, Kim ten Cate, Hugo Knaapen, Ad M. Vreman, Hendrik J. Cassee, Flemming R. Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats |
title | Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats |
title_full | Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats |
title_fullStr | Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats |
title_full_unstemmed | Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats |
title_short | Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats |
title_sort | diesel engine exhaust initiates a sequence of pulmonary and cardiovascular effects in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968117/ https://www.ncbi.nlm.nih.gov/pubmed/21052503 http://dx.doi.org/10.1155/2010/206057 |
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