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7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide
The reaction of 5-azido-5-deoxy-2,3-O-isopropylidene-2-C-methyl-d-ribose with N,N-diethyl-2-(dimethylsulfuranylidene)acetamide gave the title compound, C(15)H(26)N(4)O(5), as the major product arising from initial formation of an epoxide which was subsequently opened by intramolecular attack of...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968166/ https://www.ncbi.nlm.nih.gov/pubmed/21581878 http://dx.doi.org/10.1107/S1600536808044279 |
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author | Jenkinson, Sarah F. Wang, Chen Pino-González, Maria-Soledad Fleet, George W. J. Watkin, David J. |
author_facet | Jenkinson, Sarah F. Wang, Chen Pino-González, Maria-Soledad Fleet, George W. J. Watkin, David J. |
author_sort | Jenkinson, Sarah F. |
collection | PubMed |
description | The reaction of 5-azido-5-deoxy-2,3-O-isopropylidene-2-C-methyl-d-ribose with N,N-diethyl-2-(dimethylsulfuranylidene)acetamide gave the title compound, C(15)H(26)N(4)O(5), as the major product arising from initial formation of an epoxide which was subsequently opened by intramolecular attack of the free 4-hydroxyl group. X-ray crystallography confirmed the relative stereochemistry of the title compound and the absolute configuration was determined by the use of d-ribose as the starting material. The crystal structure contains chains of molecules running parallel to the a axis, being linked by weak bifurcated O—H⋯(N,N) hydrogen bonds. |
format | Text |
id | pubmed-2968166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-29681662010-12-30 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide Jenkinson, Sarah F. Wang, Chen Pino-González, Maria-Soledad Fleet, George W. J. Watkin, David J. Acta Crystallogr Sect E Struct Rep Online Organic Papers The reaction of 5-azido-5-deoxy-2,3-O-isopropylidene-2-C-methyl-d-ribose with N,N-diethyl-2-(dimethylsulfuranylidene)acetamide gave the title compound, C(15)H(26)N(4)O(5), as the major product arising from initial formation of an epoxide which was subsequently opened by intramolecular attack of the free 4-hydroxyl group. X-ray crystallography confirmed the relative stereochemistry of the title compound and the absolute configuration was determined by the use of d-ribose as the starting material. The crystal structure contains chains of molecules running parallel to the a axis, being linked by weak bifurcated O—H⋯(N,N) hydrogen bonds. International Union of Crystallography 2009-01-08 /pmc/articles/PMC2968166/ /pubmed/21581878 http://dx.doi.org/10.1107/S1600536808044279 Text en © Jenkinson et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Jenkinson, Sarah F. Wang, Chen Pino-González, Maria-Soledad Fleet, George W. J. Watkin, David J. 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide |
title | 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide |
title_full | 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide |
title_fullStr | 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide |
title_full_unstemmed | 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide |
title_short | 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide |
title_sort | 7-azido-n,n-diethyl-4,5-o-isopropylidene-4-c-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968166/ https://www.ncbi.nlm.nih.gov/pubmed/21581878 http://dx.doi.org/10.1107/S1600536808044279 |
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