rac-(4R,17S,18R,26R)-Ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate

In the title compound, C(30)H(30)N(4)O(7)S, the two spiro junctions link a planar 2-oxindole ring [with a mean deviation from the plane of 0.0319 (3) Å, a pyrrolidine ring in an envelope conformation and a thia­zolo[3,2-a]pyrimidine system. Two mol­ecules are connected into a dimer by two N—H⋯O hydr...

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Detalles Bibliográficos
Autores principales: Hou, Zhao-Hui, Zhou, Ning-Bo, He, Bin-Hong, Li, Xiao-Fang
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968168/
https://www.ncbi.nlm.nih.gov/pubmed/21581991
http://dx.doi.org/10.1107/S160053680900261X
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author Hou, Zhao-Hui
Zhou, Ning-Bo
He, Bin-Hong
Li, Xiao-Fang
author_facet Hou, Zhao-Hui
Zhou, Ning-Bo
He, Bin-Hong
Li, Xiao-Fang
author_sort Hou, Zhao-Hui
collection PubMed
description In the title compound, C(30)H(30)N(4)O(7)S, the two spiro junctions link a planar 2-oxindole ring [with a mean deviation from the plane of 0.0319 (3) Å, a pyrrolidine ring in an envelope conformation and a thia­zolo[3,2-a]pyrimidine system. Two mol­ecules are connected into a dimer by two N—H⋯O hydrogen bonds, forming an R (2) (2)(8) graph-set motif. The title compound has four stereogenic centers and appears as a racemic mixture of one single diastereoisomer (RSRR/SRSS).
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spelling pubmed-29681682010-12-30 rac-(4R,17S,18R,26R)-Ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate Hou, Zhao-Hui Zhou, Ning-Bo He, Bin-Hong Li, Xiao-Fang Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(30)H(30)N(4)O(7)S, the two spiro junctions link a planar 2-oxindole ring [with a mean deviation from the plane of 0.0319 (3) Å, a pyrrolidine ring in an envelope conformation and a thia­zolo[3,2-a]pyrimidine system. Two mol­ecules are connected into a dimer by two N—H⋯O hydrogen bonds, forming an R (2) (2)(8) graph-set motif. The title compound has four stereogenic centers and appears as a racemic mixture of one single diastereoisomer (RSRR/SRSS). International Union of Crystallography 2009-01-28 /pmc/articles/PMC2968168/ /pubmed/21581991 http://dx.doi.org/10.1107/S160053680900261X Text en © Hou et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Hou, Zhao-Hui
Zhou, Ning-Bo
He, Bin-Hong
Li, Xiao-Fang
rac-(4R,17S,18R,26R)-Ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate
title rac-(4R,17S,18R,26R)-Ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate
title_full rac-(4R,17S,18R,26R)-Ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate
title_fullStr rac-(4R,17S,18R,26R)-Ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate
title_full_unstemmed rac-(4R,17S,18R,26R)-Ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate
title_short rac-(4R,17S,18R,26R)-Ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate
title_sort rac-(4r,17s,18r,26r)-ethyl 4′-methoxy­carbonyl-5′′-(4-methoxy­phen­yl)-1′-methyl-2,3′′-dioxo-2′′,3′′-dihydro­indoline-3-spiro-2′-pyrrolidine-3′-spiro-2′′-thia­zolo[3,2-a]pyrimidine-6′′-carboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968168/
https://www.ncbi.nlm.nih.gov/pubmed/21581991
http://dx.doi.org/10.1107/S160053680900261X
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AT zhouningbo rac4r17s18r26rethyl4methoxycarbonyl54methoxyphenyl1methyl23dioxo23dihydroindoline3spiro2pyrrolidine3spiro2thiazolo32apyrimidine6carboxylate
AT hebinhong rac4r17s18r26rethyl4methoxycarbonyl54methoxyphenyl1methyl23dioxo23dihydroindoline3spiro2pyrrolidine3spiro2thiazolo32apyrimidine6carboxylate
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