Ethyl 5-(4-chloro­phen­yl)-2-[(Z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2H-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate

The title compound, C(19)H(17)ClN(2)O(5)S, was synthesized by the reaction of ethyl 6-(4-chloro­phen­yl)-2-mercapto-4-methyl-1,6-dihydro­pyrimidine-5-carboxyl­ate and dimethyl acetyl­ene­dicarboxyl­ate in methanol. In the mol­ecule, the nearly planar thia­zole ring, with a mean deviation from the pl...

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Detalles Bibliográficos
Autores principales: Hou, Zhao-Hui, Zhou, Ning-Bo, He, Bin-Hong, Li, Xiao-Fang
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968292/
https://www.ncbi.nlm.nih.gov/pubmed/21581973
http://dx.doi.org/10.1107/S1600536809002451
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author Hou, Zhao-Hui
Zhou, Ning-Bo
He, Bin-Hong
Li, Xiao-Fang
author_facet Hou, Zhao-Hui
Zhou, Ning-Bo
He, Bin-Hong
Li, Xiao-Fang
author_sort Hou, Zhao-Hui
collection PubMed
description The title compound, C(19)H(17)ClN(2)O(5)S, was synthesized by the reaction of ethyl 6-(4-chloro­phen­yl)-2-mercapto-4-methyl-1,6-dihydro­pyrimidine-5-carboxyl­ate and dimethyl acetyl­ene­dicarboxyl­ate in methanol. In the mol­ecule, the nearly planar thia­zole ring, with a mean deviation from the plane of 0.0108 (3) Å, is fused with a dihydro­pyrimidine ring in a flattened half-chair conformation.
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spelling pubmed-29682922010-12-30 Ethyl 5-(4-chloro­phen­yl)-2-[(Z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2H-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate Hou, Zhao-Hui Zhou, Ning-Bo He, Bin-Hong Li, Xiao-Fang Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(19)H(17)ClN(2)O(5)S, was synthesized by the reaction of ethyl 6-(4-chloro­phen­yl)-2-mercapto-4-methyl-1,6-dihydro­pyrimidine-5-carboxyl­ate and dimethyl acetyl­ene­dicarboxyl­ate in methanol. In the mol­ecule, the nearly planar thia­zole ring, with a mean deviation from the plane of 0.0108 (3) Å, is fused with a dihydro­pyrimidine ring in a flattened half-chair conformation. International Union of Crystallography 2009-01-23 /pmc/articles/PMC2968292/ /pubmed/21581973 http://dx.doi.org/10.1107/S1600536809002451 Text en © Hou and Li 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Hou, Zhao-Hui
Zhou, Ning-Bo
He, Bin-Hong
Li, Xiao-Fang
Ethyl 5-(4-chloro­phen­yl)-2-[(Z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2H-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate
title Ethyl 5-(4-chloro­phen­yl)-2-[(Z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2H-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate
title_full Ethyl 5-(4-chloro­phen­yl)-2-[(Z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2H-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate
title_fullStr Ethyl 5-(4-chloro­phen­yl)-2-[(Z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2H-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate
title_full_unstemmed Ethyl 5-(4-chloro­phen­yl)-2-[(Z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2H-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate
title_short Ethyl 5-(4-chloro­phen­yl)-2-[(Z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2H-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate
title_sort ethyl 5-(4-chloro­phen­yl)-2-[(z)-(methoxy­carbon­yl)methyl­ene]-7-methyl-3-oxo-3,5-dihydro-2h-thia­zolo[3,2-a]pyrimi­dine-6-carboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968292/
https://www.ncbi.nlm.nih.gov/pubmed/21581973
http://dx.doi.org/10.1107/S1600536809002451
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AT hebinhong ethyl54chlorophenyl2zmethoxycarbonylmethylene7methyl3oxo35dihydro2hthiazolo32apyrimidine6carboxylate
AT lixiaofang ethyl54chlorophenyl2zmethoxycarbonylmethylene7methyl3oxo35dihydro2hthiazolo32apyrimidine6carboxylate

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