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5-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyl­perhydro-3,12-ep­oxy-1,2-dioxepino[4,3-i]isochromen-10-yl]oxymeth­yl}benzene-1,3-diol

The title compound, C(22)H(30)O(7), is a fused five-ring system that is of inter­est for its anti­cancer and anti­malarial activity. The six-membered C(6) and C(5)O rings display chair conformations. The six-membered C(3)O(3) ring containing the ether and per­oxy functionalities has a distorted boat...

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Detalles Bibliográficos
Autores principales: Gul, Waseem, Carvalho, Paulo, Galal, Ahmed, Avery, Mitchell A., El Sohly, Mahmoud A.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968296/
https://www.ncbi.nlm.nih.gov/pubmed/21581957
http://dx.doi.org/10.1107/S1600536809002050
Descripción
Sumario:The title compound, C(22)H(30)O(7), is a fused five-ring system that is of inter­est for its anti­cancer and anti­malarial activity. The six-membered C(6) and C(5)O rings display chair conformations. The six-membered C(3)O(3) ring containing the ether and per­oxy functionalities has a distorted boat conformation, with a C—O—O—C torsion angle of 42.6 (1)° for the per­oxy group. The seven-membered C(6)O ring has a distorted boat-type conformation, while the seven-membered C(5)O(2) ring has a very distorted chair-type conformation. The structure contains inter­molecular O—H⋯O and O—H⋯(O,O) bonds that link the mol­ecules into sheets parallel to the (100) planes.