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5-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethylperhydro-3,12-epoxy-1,2-dioxepino[4,3-i]isochromen-10-yl]oxymethyl}benzene-1,3-diol
The title compound, C(22)H(30)O(7), is a fused five-ring system that is of interest for its anticancer and antimalarial activity. The six-membered C(6) and C(5)O rings display chair conformations. The six-membered C(3)O(3) ring containing the ether and peroxy functionalities has a distorted boat...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968296/ https://www.ncbi.nlm.nih.gov/pubmed/21581957 http://dx.doi.org/10.1107/S1600536809002050 |
Sumario: | The title compound, C(22)H(30)O(7), is a fused five-ring system that is of interest for its anticancer and antimalarial activity. The six-membered C(6) and C(5)O rings display chair conformations. The six-membered C(3)O(3) ring containing the ether and peroxy functionalities has a distorted boat conformation, with a C—O—O—C torsion angle of 42.6 (1)° for the peroxy group. The seven-membered C(6)O ring has a distorted boat-type conformation, while the seven-membered C(5)O(2) ring has a very distorted chair-type conformation. The structure contains intermolecular O—H⋯O and O—H⋯(O,O) bonds that link the molecules into sheets parallel to the (100) planes. |
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