IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection

IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that...

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Detalles Bibliográficos
Autores principales: Ashman, Robert B., Vijayan, Dipti, Wells, Christine A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968417/
https://www.ncbi.nlm.nih.gov/pubmed/21052539
http://dx.doi.org/10.1155/2011/686597
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author Ashman, Robert B.
Vijayan, Dipti
Wells, Christine A.
author_facet Ashman, Robert B.
Vijayan, Dipti
Wells, Christine A.
author_sort Ashman, Robert B.
collection PubMed
description IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.
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spelling pubmed-29684172010-11-04 IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection Ashman, Robert B. Vijayan, Dipti Wells, Christine A. Clin Dev Immunol Review Article IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them. Hindawi Publishing Corporation 2011 2010-11-01 /pmc/articles/PMC2968417/ /pubmed/21052539 http://dx.doi.org/10.1155/2011/686597 Text en Copyright © 2011 Robert B. Ashman et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ashman, Robert B.
Vijayan, Dipti
Wells, Christine A.
IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
title IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
title_full IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
title_fullStr IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
title_full_unstemmed IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
title_short IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
title_sort il-12 and related cytokines: function and regulatory implications in candida albicans infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968417/
https://www.ncbi.nlm.nih.gov/pubmed/21052539
http://dx.doi.org/10.1155/2011/686597
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