The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both

Gestational diabetes mellitus (GDM) is defined as the glucose intolerance that is not present or recognized prior to pregnancy. Several risk factors of GDM depend on environmental factors that are thought to regulate the genome through epigenetic mechanisms. Thus, epigenetic regulation could be invo...

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Detalles Bibliográficos
Autores principales: Fernández-Morera, J. L., Rodríguez-Rodero, S., Menéndez-Torre, E., Fraga, M. F.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968420/
https://www.ncbi.nlm.nih.gov/pubmed/21052542
http://dx.doi.org/10.1155/2010/605163
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author Fernández-Morera, J. L.
Rodríguez-Rodero, S.
Menéndez-Torre, E.
Fraga, M. F.
author_facet Fernández-Morera, J. L.
Rodríguez-Rodero, S.
Menéndez-Torre, E.
Fraga, M. F.
author_sort Fernández-Morera, J. L.
collection PubMed
description Gestational diabetes mellitus (GDM) is defined as the glucose intolerance that is not present or recognized prior to pregnancy. Several risk factors of GDM depend on environmental factors that are thought to regulate the genome through epigenetic mechanisms. Thus, epigenetic regulation could be involved in the development of GDM. In addition, the adverse intrauterine environment in patients with GDM could also have a negative impact on the establishment of the epigenomes of the offspring.
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spelling pubmed-29684202010-11-04 The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both Fernández-Morera, J. L. Rodríguez-Rodero, S. Menéndez-Torre, E. Fraga, M. F. Obstet Gynecol Int Review Article Gestational diabetes mellitus (GDM) is defined as the glucose intolerance that is not present or recognized prior to pregnancy. Several risk factors of GDM depend on environmental factors that are thought to regulate the genome through epigenetic mechanisms. Thus, epigenetic regulation could be involved in the development of GDM. In addition, the adverse intrauterine environment in patients with GDM could also have a negative impact on the establishment of the epigenomes of the offspring. Hindawi Publishing Corporation 2010 2010-10-31 /pmc/articles/PMC2968420/ /pubmed/21052542 http://dx.doi.org/10.1155/2010/605163 Text en Copyright © 2010 J. L. Fernández-Morera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fernández-Morera, J. L.
Rodríguez-Rodero, S.
Menéndez-Torre, E.
Fraga, M. F.
The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both
title The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both
title_full The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both
title_fullStr The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both
title_full_unstemmed The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both
title_short The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both
title_sort possible role of epigenetics in gestational diabetes: cause, consequence, or both
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968420/
https://www.ncbi.nlm.nih.gov/pubmed/21052542
http://dx.doi.org/10.1155/2010/605163
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