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N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
In the crystal structure of the title compound, C(18)H(18)N(2)O(4)S, the thiazine ring adopts a distorted half-chair conformation. 1,2-Benzothiazines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis....
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968491/ https://www.ncbi.nlm.nih.gov/pubmed/21582293 http://dx.doi.org/10.1107/S1600536809006837 |
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author | Siddiqui, Waseeq Ahmad Bukahari, Iftikhar Hussain Zia-ur-Rehman, Muhammad Khan, Islam Ullah Tizzard, Graham John |
author_facet | Siddiqui, Waseeq Ahmad Bukahari, Iftikhar Hussain Zia-ur-Rehman, Muhammad Khan, Islam Ullah Tizzard, Graham John |
author_sort | Siddiqui, Waseeq Ahmad |
collection | PubMed |
description | In the crystal structure of the title compound, C(18)H(18)N(2)O(4)S, the thiazine ring adopts a distorted half-chair conformation. 1,2-Benzothiazines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis. The enolic H atom is involved in an intramolecular O—H⋯O hydrogen bond, forming a six-membered ring. The molecules arrange themselves into centrosymmetric dimers by means of intermolecular N—H⋯O hydrogen bonds. A weak intermolcular C—H⋯O interaction is also present. |
format | Text |
id | pubmed-2968491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-29684912010-12-30 N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide Siddiqui, Waseeq Ahmad Bukahari, Iftikhar Hussain Zia-ur-Rehman, Muhammad Khan, Islam Ullah Tizzard, Graham John Acta Crystallogr Sect E Struct Rep Online Organic Papers In the crystal structure of the title compound, C(18)H(18)N(2)O(4)S, the thiazine ring adopts a distorted half-chair conformation. 1,2-Benzothiazines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis. The enolic H atom is involved in an intramolecular O—H⋯O hydrogen bond, forming a six-membered ring. The molecules arrange themselves into centrosymmetric dimers by means of intermolecular N—H⋯O hydrogen bonds. A weak intermolcular C—H⋯O interaction is also present. International Union of Crystallography 2009-02-28 /pmc/articles/PMC2968491/ /pubmed/21582293 http://dx.doi.org/10.1107/S1600536809006837 Text en © Siddiqui et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Siddiqui, Waseeq Ahmad Bukahari, Iftikhar Hussain Zia-ur-Rehman, Muhammad Khan, Islam Ullah Tizzard, Graham John N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
title |
N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
title_full |
N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
title_fullStr |
N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
title_full_unstemmed |
N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
title_short |
N-(2,3-Dimethylphenyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
title_sort | n-(2,3-dimethylphenyl)-4-hydroxy-2-methyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968491/ https://www.ncbi.nlm.nih.gov/pubmed/21582293 http://dx.doi.org/10.1107/S1600536809006837 |
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