Cargando…

N-(2,3-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide

In the crystal structure of the title compound, C(18)H(18)N(2)O(4)S, the thia­zine ring adopts a distorted half-chair conformation. 1,2-Benzothia­zines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis....

Descripción completa

Detalles Bibliográficos
Autores principales: Siddiqui, Waseeq Ahmad, Bukahari, Iftikhar Hussain, Zia-ur-Rehman, Muhammad, Khan, Islam Ullah, Tizzard, Graham John
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968491/
https://www.ncbi.nlm.nih.gov/pubmed/21582293
http://dx.doi.org/10.1107/S1600536809006837
_version_ 1782189892810309632
author Siddiqui, Waseeq Ahmad
Bukahari, Iftikhar Hussain
Zia-ur-Rehman, Muhammad
Khan, Islam Ullah
Tizzard, Graham John
author_facet Siddiqui, Waseeq Ahmad
Bukahari, Iftikhar Hussain
Zia-ur-Rehman, Muhammad
Khan, Islam Ullah
Tizzard, Graham John
author_sort Siddiqui, Waseeq Ahmad
collection PubMed
description In the crystal structure of the title compound, C(18)H(18)N(2)O(4)S, the thia­zine ring adopts a distorted half-chair conformation. 1,2-Benzothia­zines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis. The enolic H atom is involved in an intra­molecular O—H⋯O hydrogen bond, forming a six-membered ring. The mol­ecules arrange themselves into centrosymmetric dimers by means of inter­molecular N—H⋯O hydrogen bonds. A weak inter­molcular C—H⋯O inter­action is also present.
format Text
id pubmed-2968491
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-29684912010-12-30 N-(2,3-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide Siddiqui, Waseeq Ahmad Bukahari, Iftikhar Hussain Zia-ur-Rehman, Muhammad Khan, Islam Ullah Tizzard, Graham John Acta Crystallogr Sect E Struct Rep Online Organic Papers In the crystal structure of the title compound, C(18)H(18)N(2)O(4)S, the thia­zine ring adopts a distorted half-chair conformation. 1,2-Benzothia­zines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis. The enolic H atom is involved in an intra­molecular O—H⋯O hydrogen bond, forming a six-membered ring. The mol­ecules arrange themselves into centrosymmetric dimers by means of inter­molecular N—H⋯O hydrogen bonds. A weak inter­molcular C—H⋯O inter­action is also present. International Union of Crystallography 2009-02-28 /pmc/articles/PMC2968491/ /pubmed/21582293 http://dx.doi.org/10.1107/S1600536809006837 Text en © Siddiqui et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Siddiqui, Waseeq Ahmad
Bukahari, Iftikhar Hussain
Zia-ur-Rehman, Muhammad
Khan, Islam Ullah
Tizzard, Graham John
N-(2,3-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title N-(2,3-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_full N-(2,3-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_fullStr N-(2,3-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_full_unstemmed N-(2,3-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_short N-(2,3-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_sort n-(2,3-dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2h-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968491/
https://www.ncbi.nlm.nih.gov/pubmed/21582293
http://dx.doi.org/10.1107/S1600536809006837
work_keys_str_mv AT siddiquiwaseeqahmad n23dimethylphenyl4hydroxy2methyl2h12benzothiazine3carboxamide11dioxide
AT bukahariiftikharhussain n23dimethylphenyl4hydroxy2methyl2h12benzothiazine3carboxamide11dioxide
AT ziaurrehmanmuhammad n23dimethylphenyl4hydroxy2methyl2h12benzothiazine3carboxamide11dioxide
AT khanislamullah n23dimethylphenyl4hydroxy2methyl2h12benzothiazine3carboxamide11dioxide
AT tizzardgrahamjohn n23dimethylphenyl4hydroxy2methyl2h12benzothiazine3carboxamide11dioxide