2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol

The title compound, C(21)H(24)Br(2)N(2)O(3), was synthesized by the condensation reaction of 3-methoxy­salicylaldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)cyclo­hexa­nol in a methanol solution. The dihedral angle between the two benzene rings is 76.4 (3)°. The cyclo­hexyl ring adopts a chair co...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhi-Gang, Wang, Rong, Zhang, Yi, Zhi, Feng, Yang, Yi-Lin
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968568/
https://www.ncbi.nlm.nih.gov/pubmed/21582209
http://dx.doi.org/10.1107/S1600536809005182
_version_ 1782189917677289472
author Wang, Zhi-Gang
Wang, Rong
Zhang, Yi
Zhi, Feng
Yang, Yi-Lin
author_facet Wang, Zhi-Gang
Wang, Rong
Zhang, Yi
Zhi, Feng
Yang, Yi-Lin
author_sort Wang, Zhi-Gang
collection PubMed
description The title compound, C(21)H(24)Br(2)N(2)O(3), was synthesized by the condensation reaction of 3-methoxy­salicylaldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)cyclo­hexa­nol in a methanol solution. The dihedral angle between the two benzene rings is 76.4 (3)°. The cyclo­hexyl ring adopts a chair configuration. There is an intra­molecular O—H⋯N hydrogen bond which affects the solid state conformation of the mol­ecule. The crystal structure is stabilized by inter­molecular O—H⋯O hydrogen bonds, forming chains running along the b axis.
format Text
id pubmed-2968568
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-29685682010-12-30 2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol Wang, Zhi-Gang Wang, Rong Zhang, Yi Zhi, Feng Yang, Yi-Lin Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(21)H(24)Br(2)N(2)O(3), was synthesized by the condensation reaction of 3-methoxy­salicylaldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)cyclo­hexa­nol in a methanol solution. The dihedral angle between the two benzene rings is 76.4 (3)°. The cyclo­hexyl ring adopts a chair configuration. There is an intra­molecular O—H⋯N hydrogen bond which affects the solid state conformation of the mol­ecule. The crystal structure is stabilized by inter­molecular O—H⋯O hydrogen bonds, forming chains running along the b axis. International Union of Crystallography 2009-02-18 /pmc/articles/PMC2968568/ /pubmed/21582209 http://dx.doi.org/10.1107/S1600536809005182 Text en © Wang et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Wang, Zhi-Gang
Wang, Rong
Zhang, Yi
Zhi, Feng
Yang, Yi-Lin
2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol
title 2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol
title_full 2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol
title_fullStr 2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol
title_full_unstemmed 2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol
title_short 2-[6,8-Dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol
title_sort 2-[6,8-dibromo-3-(4-hydroxy­cyclo­hexyl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]-6-methoxy­phenol
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968568/
https://www.ncbi.nlm.nih.gov/pubmed/21582209
http://dx.doi.org/10.1107/S1600536809005182
work_keys_str_mv AT wangzhigang 268dibromo34hydroxycyclohexyl1234tetrahydroquinazolin2yl6methoxyphenol
AT wangrong 268dibromo34hydroxycyclohexyl1234tetrahydroquinazolin2yl6methoxyphenol
AT zhangyi 268dibromo34hydroxycyclohexyl1234tetrahydroquinazolin2yl6methoxyphenol
AT zhifeng 268dibromo34hydroxycyclohexyl1234tetrahydroquinazolin2yl6methoxyphenol
AT yangyilin 268dibromo34hydroxycyclohexyl1234tetrahydroquinazolin2yl6methoxyphenol

Ejemplares similares