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The Clinical Importance of the Heterogeneity of HER2 neu

We report on a patient with breast cancer in whom there were areas of the tumor that were 3+ positive and negative for HER2 neu by immunohistochemistry, adjacent to each other. Depending on the area tested the results were completely different. The clinical implications are important. We recommend r...

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Detalles Bibliográficos
Autores principales: Davila, Enrique, Amazon, Kip
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968767/
https://www.ncbi.nlm.nih.gov/pubmed/21045934
http://dx.doi.org/10.1159/000319020
Descripción
Sumario:We report on a patient with breast cancer in whom there were areas of the tumor that were 3+ positive and negative for HER2 neu by immunohistochemistry, adjacent to each other. Depending on the area tested the results were completely different. The clinical implications are important. We recommend retesting a large portion of the tumor in all cases of initially negative test results.