The Clinical Importance of the Heterogeneity of HER2 neu

We report on a patient with breast cancer in whom there were areas of the tumor that were 3+ positive and negative for HER2 neu by immunohistochemistry, adjacent to each other. Depending on the area tested the results were completely different. The clinical implications are important. We recommend r...

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Detalles Bibliográficos
Autores principales: Davila, Enrique, Amazon, Kip
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2010
Materias:
Published: July 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968767/
https://www.ncbi.nlm.nih.gov/pubmed/21045934
http://dx.doi.org/10.1159/000319020
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author Davila, Enrique
Amazon, Kip
author_facet Davila, Enrique
Amazon, Kip
author_sort Davila, Enrique
collection PubMed
description We report on a patient with breast cancer in whom there were areas of the tumor that were 3+ positive and negative for HER2 neu by immunohistochemistry, adjacent to each other. Depending on the area tested the results were completely different. The clinical implications are important. We recommend retesting a large portion of the tumor in all cases of initially negative test results.
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spelling pubmed-29687672010-11-02 The Clinical Importance of the Heterogeneity of HER2 neu Davila, Enrique Amazon, Kip Case Rep Oncol Published: July 2010 We report on a patient with breast cancer in whom there were areas of the tumor that were 3+ positive and negative for HER2 neu by immunohistochemistry, adjacent to each other. Depending on the area tested the results were completely different. The clinical implications are important. We recommend retesting a large portion of the tumor in all cases of initially negative test results. S. Karger AG 2010-07-24 /pmc/articles/PMC2968767/ /pubmed/21045934 http://dx.doi.org/10.1159/000319020 Text en Copyright © 2010 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ © 2010 S. Karger AG, Basel. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: July 2010
Davila, Enrique
Amazon, Kip
The Clinical Importance of the Heterogeneity of HER2 neu
title The Clinical Importance of the Heterogeneity of HER2 neu
title_full The Clinical Importance of the Heterogeneity of HER2 neu
title_fullStr The Clinical Importance of the Heterogeneity of HER2 neu
title_full_unstemmed The Clinical Importance of the Heterogeneity of HER2 neu
title_short The Clinical Importance of the Heterogeneity of HER2 neu
title_sort clinical importance of the heterogeneity of her2 neu
topic Published: July 2010
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968767/
https://www.ncbi.nlm.nih.gov/pubmed/21045934
http://dx.doi.org/10.1159/000319020
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