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(R)-4-[2-(Methyl­sulfanyl)pyrimidin-4-yl]-1-(tetra­hydro­furan-3-yl)-1H-pyrazol-5-amine

The title compound, C(12)H(15)N(5)OS, was obtained by reaction of 2-(2-(methyl­thio)pyrimidin-4-yl)-3-oxopropane­nitrile with (tetra­hydro­furan-3-yl)hydrazine dihydro­chloride, and the racemic product was subsequently separated by chiral chromatography (first peak; [α](D) (20) = +51.3°). The chiral...

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Detalles Bibliográficos
Autores principales: Liu, Zhengyu, Liu, Kevin K.-C., Elleraas, Jeff, Rheingold, Arnold L., DiPasquale, Antonio, Yanovsky, Alex
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968870/
https://www.ncbi.nlm.nih.gov/pubmed/21582437
http://dx.doi.org/10.1107/S160053680900734X
Descripción
Sumario:The title compound, C(12)H(15)N(5)OS, was obtained by reaction of 2-(2-(methyl­thio)pyrimidin-4-yl)-3-oxopropane­nitrile with (tetra­hydro­furan-3-yl)hydrazine dihydro­chloride, and the racemic product was subsequently separated by chiral chromatography (first peak; [α](D) (20) = +51.3°). The chiral center at the substituted atom of the tetra­hydro­furanyl group has an R-configuration. The pyrimidine and pyrazolyl rings are almost coplanar, their mean planes forming a dihedral angle of 6.4 (1)°. One of the H atoms of the amino group participates in an intra­molecular hydrogen bond with the pyrimidine N atom in position 3. The second H atom is involved in an inter­molecular hydrogen bond, which links the mol­ecules into an infinite chain.