3α,4α-Ep­oxy-5α-androstan-17β-yl acetate

The title compound, C(21)H(32)O(3), results from modifications of the A and D rings of the aromatase substrate androstenedione. Ring A adopts a conformation between 10β-sofa and 1α,10β half-chair. Rings B and C are in slightly flattened chair conformations. Ring D approaches a 13β-envelope conformat...

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Detalles Bibliográficos
Autores principales: Andrade, L. C.R., Paixão, J. A., de Almeida, M.J.M., Fernandes Roleira, F. M., Tavares da Silva, E. J.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968911/
https://www.ncbi.nlm.nih.gov/pubmed/21582535
http://dx.doi.org/10.1107/S160053680900899X
Descripción
Sumario:The title compound, C(21)H(32)O(3), results from modifications of the A and D rings of the aromatase substrate androstenedione. Ring A adopts a conformation between 10β-sofa and 1α,10β half-chair. Rings B and C are in slightly flattened chair conformations. Ring D approaches a 13β-envelope conformation, probably due to the acet­oxy substituent, and shows a very short Csp (3)—Csp (3) bond next to the epoxide ring, which is characteristic of 3–4 epoxides. .

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