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3α,4α-Epoxy-5α-androstan-17β-yl acetate
The title compound, C(21)H(32)O(3), results from modifications of the A and D rings of the aromatase substrate androstenedione. Ring A adopts a conformation between 10β-sofa and 1α,10β half-chair. Rings B and C are in slightly flattened chair conformations. Ring D approaches a 13β-envelope conformat...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968911/ https://www.ncbi.nlm.nih.gov/pubmed/21582535 http://dx.doi.org/10.1107/S160053680900899X |
| _version_ | 1782190005867773952 |
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| author | Andrade, L. C.R. Paixão, J. A. de Almeida, M.J.M. Fernandes Roleira, F. M. Tavares da Silva, E. J. |
| author_facet | Andrade, L. C.R. Paixão, J. A. de Almeida, M.J.M. Fernandes Roleira, F. M. Tavares da Silva, E. J. |
| author_sort | Andrade, L. C.R. |
| collection | PubMed |
| description | The title compound, C(21)H(32)O(3), results from modifications of the A and D rings of the aromatase substrate androstenedione. Ring A adopts a conformation between 10β-sofa and 1α,10β half-chair. Rings B and C are in slightly flattened chair conformations. Ring D approaches a 13β-envelope conformation, probably due to the acetoxy substituent, and shows a very short Csp (3)—Csp (3) bond next to the epoxide ring, which is characteristic of 3–4 epoxides. . |
| format | Text |
| id | pubmed-2968911 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29689112010-12-30 3α,4α-Epoxy-5α-androstan-17β-yl acetate Andrade, L. C.R. Paixão, J. A. de Almeida, M.J.M. Fernandes Roleira, F. M. Tavares da Silva, E. J. Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(21)H(32)O(3), results from modifications of the A and D rings of the aromatase substrate androstenedione. Ring A adopts a conformation between 10β-sofa and 1α,10β half-chair. Rings B and C are in slightly flattened chair conformations. Ring D approaches a 13β-envelope conformation, probably due to the acetoxy substituent, and shows a very short Csp (3)—Csp (3) bond next to the epoxide ring, which is characteristic of 3–4 epoxides. . International Union of Crystallography 2009-03-25 /pmc/articles/PMC2968911/ /pubmed/21582535 http://dx.doi.org/10.1107/S160053680900899X Text en © Andrade et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Organic Papers Andrade, L. C.R. Paixão, J. A. de Almeida, M.J.M. Fernandes Roleira, F. M. Tavares da Silva, E. J. 3α,4α-Epoxy-5α-androstan-17β-yl acetate |
| title | 3α,4α-Epoxy-5α-androstan-17β-yl acetate |
| title_full | 3α,4α-Epoxy-5α-androstan-17β-yl acetate |
| title_fullStr | 3α,4α-Epoxy-5α-androstan-17β-yl acetate |
| title_full_unstemmed | 3α,4α-Epoxy-5α-androstan-17β-yl acetate |
| title_short | 3α,4α-Epoxy-5α-androstan-17β-yl acetate |
| title_sort | 3α,4α-epoxy-5α-androstan-17β-yl acetate |
| topic | Organic Papers |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968911/ https://www.ncbi.nlm.nih.gov/pubmed/21582535 http://dx.doi.org/10.1107/S160053680900899X |
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