N-(3,4-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide

1,2-Benzothia­zines similar to the title compound, C(18)H(18)N(2)O(4)S, are well known in the literature for their biological activities and are used as medicines in the treatment of inflammation and rheumatoid arthritis. The thia­zine ring adopts a distorted half-chair conformation. The enolic H at...

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Detalles Bibliográficos
Autores principales: Siddiqui, Waseeq Ahmad, Ali, Muhammad, Zia-ur-Rehman, Muhammad, Sharif, Saima, Tizzard, Graham John
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968962/
https://www.ncbi.nlm.nih.gov/pubmed/21582605
http://dx.doi.org/10.1107/S1600536809010058
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author Siddiqui, Waseeq Ahmad
Ali, Muhammad
Zia-ur-Rehman, Muhammad
Sharif, Saima
Tizzard, Graham John
author_facet Siddiqui, Waseeq Ahmad
Ali, Muhammad
Zia-ur-Rehman, Muhammad
Sharif, Saima
Tizzard, Graham John
author_sort Siddiqui, Waseeq Ahmad
collection PubMed
description 1,2-Benzothia­zines similar to the title compound, C(18)H(18)N(2)O(4)S, are well known in the literature for their biological activities and are used as medicines in the treatment of inflammation and rheumatoid arthritis. The thia­zine ring adopts a distorted half-chair conformation. The enolic H atom is involved in an intra­molecular O—H⋯O hydrogen bond, forming a six-membered ring. In the crystal, mol­ecules arrange themselves into centrosymmetric dimers by means of pairs of weak inter­molecular N—H⋯O hydrogen bonds.
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spelling pubmed-29689622010-12-30 N-(3,4-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide Siddiqui, Waseeq Ahmad Ali, Muhammad Zia-ur-Rehman, Muhammad Sharif, Saima Tizzard, Graham John Acta Crystallogr Sect E Struct Rep Online Organic Papers 1,2-Benzothia­zines similar to the title compound, C(18)H(18)N(2)O(4)S, are well known in the literature for their biological activities and are used as medicines in the treatment of inflammation and rheumatoid arthritis. The thia­zine ring adopts a distorted half-chair conformation. The enolic H atom is involved in an intra­molecular O—H⋯O hydrogen bond, forming a six-membered ring. In the crystal, mol­ecules arrange themselves into centrosymmetric dimers by means of pairs of weak inter­molecular N—H⋯O hydrogen bonds. International Union of Crystallography 2009-03-28 /pmc/articles/PMC2968962/ /pubmed/21582605 http://dx.doi.org/10.1107/S1600536809010058 Text en © Siddiqui et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Siddiqui, Waseeq Ahmad
Ali, Muhammad
Zia-ur-Rehman, Muhammad
Sharif, Saima
Tizzard, Graham John
N-(3,4-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title N-(3,4-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_full N-(3,4-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_fullStr N-(3,4-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_full_unstemmed N-(3,4-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_short N-(3,4-Dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2H-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
title_sort n-(3,4-dimethyl­phen­yl)-4-hydr­oxy-2-methyl-2h-1,2-benzothia­zine-3-carboxamide 1,1-dioxide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968962/
https://www.ncbi.nlm.nih.gov/pubmed/21582605
http://dx.doi.org/10.1107/S1600536809010058
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