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Darifenacin hydro­bromide

In the title compound {systematic name: (S)-3-[(aminocar­bonyl)diphenylmethyl]-1-[2-(2,3-di­hy­dro­benzofuran-5-yl)ethyl]pyrrolidinium bromide}, C(28)H(31)N(2)O(2) (+)·Br(−), the pyrrolidine rings adopts an envelope conformation. The two phenyl rings make a dihedral angle of 72.5 (1)°. The four copl...

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Detalles Bibliográficos
Autores principales: Selvanayagam, S., Sridhar, B., Ravikumar, K.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2969553/
https://www.ncbi.nlm.nih.gov/pubmed/21583148
http://dx.doi.org/10.1107/S1600536809017085
Descripción
Sumario:In the title compound {systematic name: (S)-3-[(aminocar­bonyl)diphenylmethyl]-1-[2-(2,3-di­hy­dro­benzofuran-5-yl)ethyl]pyrrolidinium bromide}, C(28)H(31)N(2)O(2) (+)·Br(−), the pyrrolidine rings adopts an envelope conformation. The two phenyl rings make a dihedral angle of 72.5 (1)°. The four coplanar atoms of the pyrrolidine ring makes dihedral angles of 33.1 (2) and 82.8 (2)° with the two phenyl rings. The mol­ecular conformation is influenced by a C—H⋯O inter­action. In the crystal packing, there are two N—H⋯Br hydrogen bonds running in opposite directions. They appear to form C(10) and C(9) chain motifs in the unit cell. In addition, the mol­ecular packing is further stabilized by C—H⋯Br and C—H⋯O hydrogen bonds. The C atom bonded to the benzofuran ring system is disordered in a 0.66:0.34 ratio.