Methyl 5,6-dimeth­oxy-1H-indole-2-carboxyl­ate

The title compound, C(12)H(13)NO(4), was prepared as a precursor to an indole derivative with possible anti­mitotic properties. The mol­ecule is very nearly planar; the maximum deviation of any non-H atom from the mean plane of the indole ring is 0.120 (3) Å for each of two meth­oxy C atoms. The pai...

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Detalles Bibliográficos
Autores principales: Monroe, Thomas Blake, Moazami, Yasamin, Jones, Daniel S., Ogle, Craig A.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970210/
https://www.ncbi.nlm.nih.gov/pubmed/21577822
http://dx.doi.org/10.1107/S1600536809034667
Descripción
Sumario:The title compound, C(12)H(13)NO(4), was prepared as a precursor to an indole derivative with possible anti­mitotic properties. The mol­ecule is very nearly planar; the maximum deviation of any non-H atom from the mean plane of the indole ring is 0.120 (3) Å for each of two meth­oxy C atoms. The pairs of mol­ecules related by the inversion centre at (0,0,[Image: see text]) are connected by two symmetry-equivalent N—H⋯O hydrogen bonds, while the pairs of mol­ecules related by the inversion centre at (0,0,0) exhibit a π-stacking inter­action of the indole rings, with an inter­planar separation of 3.39 (3) Å.

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