Cargando…

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such as rosiglitazone, PPAR-γ regulates adipogenes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Jun, Ghosh, Asish K., Sargent, Jennifer L., Komura, Kazuhiro, Wu, Minghua, Huang, Qi-Quan, Jain, Manu, Whitfield, Michael L., Feghali-Bostwick, Carol, Varga, John
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970611/ https://www.ncbi.nlm.nih.gov/pubmed/21072170 http://dx.doi.org/10.1371/journal.pone.0013778

Ejemplares similares

Fibroblasts in fibrosis: novel roles and mediators
por: Kendall, Ryan T., et al.
Publicado: (2014)

Regulation of Matrix Remodeling by Peroxisome Proliferator-Activated Receptor-γ: A Novel Link Between Metabolism and Fibrogenesis
por: Wei, Jun, et al.
Publicado: (2012)

Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts
por: Steinman, Richard A., et al.
Publicado: (2012)

GDF5 Regulates TGFß-Dependent Angiogenesis in Breast Carcinoma MCF-7 Cells: In Vitro and In Vivo Control by Anti-TGFß Peptides
por: Margheri, Francesca, et al.
Publicado: (2012)

The Model of PPARγ-Downregulated Signaling in Psoriasis
por: Sobolev, Vladimir, et al.
Publicado: (2020)

Patients with idiopathic recurrent miscarriage have abnormally high TGFß+ blood NK, NKT and T cells in the presence of abnormally low TGFß plasma levels
por: Zhu, Li, et al.
Publicado: (2019)

LRG1 promotes angiogenesis by modulating endothelial TGFß signalling
por: Wang, Xiaomeng, et al.
Publicado: (2013)

Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors
por: Schumacher, Justin D., et al.
Publicado: (2016)

PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1
por: Takamura, Naoko, et al.
Publicado: (2021)

Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis
por: Artlett, Carol M., et al.
Publicado: (2017)

Eggshell membrane ameliorates hepatic fibrogenesis in human C3A cells and rats through changes in PPARγ-Endothelin 1 signaling
por: Jia, Huijuan, et al.
Publicado: (2014)

A Dynein Motor Attachment Complex Regulates TGFß/Smad3 Signaling
por: Jin, Qunyan, et al.
Publicado: (2013)

Generation of Rat Embryonic Germ Cells via Inhibition of TGFß and MEK Pathways
por: Mohammadi, Alireza, et al.
Publicado: (2015)

Insulin-Like Growth Factor Binding Proteins-3 and -5: Central Mediators of Fibrosis and Promising New Therapeutic Targets
por: Veraldi, Kristen L, et al.
Publicado: (2012)

Fibrogenesis
por: Harington, J. S.
Publicado: (1974)

Fibrogenesis
por: Munger, John S., et al.
Publicado: (2010)

First Characterization of the Transcriptome of Lung Fibroblasts of SSc Patients and Healthy Donors of African Ancestry
por: Renaud, Ludivine, et al.
Publicado: (2023)

Loss of PPARγ expression by fibroblasts enhances dermal wound closure
por: Sha, Wei, et al.
Publicado: (2012)

Proteomic landscape of TGF-β1-induced fibrogenesis in renal fibroblasts
por: Zhou, Shujun, et al.
Publicado: (2020)

The Molecular Mechanisms of Systemic Sclerosis-Associated Lung Fibrosis
por: Mouawad, Joe E., et al.
Publicado: (2023)

382 The Role of the IL-6-IGF-II Axis in Systemic Sclerosis-Associated Lung Fibrosis
por: Adewale, Adegboyega Timothy, et al.
Publicado: (2023)

Periostin plays a critical role in the cell cycle in lung fibroblasts
por: Yoshihara, Tomohito, et al.
Publicado: (2020)

Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts
por: Hadjicharalambous, Marina R., et al.
Publicado: (2018)

Glucose intolerance after chronic stress is related with downregulated PPAR-γ in adipose tissue
por: Pereira, Vitor H., et al.
Publicado: (2016)

MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional Network
por: Juiz-Valiña, Paula, et al.
Publicado: (2022)

Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis
por: Hadjicharalambous, Marina R., et al.
Publicado: (2019)

T Cell-Specific Overexpression of TGFß1 Fails to Influence Atherosclerosis in ApoE-Deficient Mice
por: Reifenberg, Kurt, et al.
Publicado: (2013)

The Effects of Post-Mating Administration of Anti-IL-10 and Anti-TGFß on Conception Rates in Mice
por: Risvanli, Ali, et al.
Publicado: (2015)

IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF
por: Su, Yunyun, et al.
Publicado: (2015)

Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis
por: Wang, Yating, et al.
Publicado: (2020)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism through PPARγ2 Downregulation
por: Park, Chung-Hwa, et al.
Publicado: (2017)

TGF-β is insufficient to induce adipocyte state loss without concurrent PPARγ downregulation
por: Taylor, Brooks, et al.
Publicado: (2020)

Functional role of PPAR-γ on the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis
por: Li, Xiao-Feng, et al.
Publicado: (2017)

Amniotic Membrane Modifies the Genetic Program Induced by TGFß, Stimulating Keratinocyte Proliferation and Migration in Chronic Wounds
por: Alcaraz, Antonia, et al.
Publicado: (2015)

AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
por: Yao, Catherine D., et al.
Publicado: (2020)

Underexpression of peroxisome proliferator-activated receptor (PPAR)γ in PAX8/PPARγ-negative thyroid tumours
por: Marques, A R, et al.
Publicado: (2004)

Linagliptin Limits High Glucose Induced Conversion of Latent to Active TGFß through Interaction with CIM6PR and Limits Renal Tubulointerstitial Fibronectin
por: Gangadharan Komala, Muralikrishna, et al.
Publicado: (2015)

The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis
por: Yasuoka, Hidekata, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_e4ulutg1f6g8181v7gspetblsh