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Stromal Fibroblasts in Digestive Cancer

The normal gastrointestinal stroma consists of extra-cellular matrix and a community of stromal cells including fibroblasts, myofibroblasts, smooth muscle cells, pericytes, endothelium and inflammatory cells. α-smooth muscle actin (α-SMA) positive stromal fibroblasts, often referred to as myofibrobl...

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Detalles Bibliográficos
Autores principales: Worthley, Daniel L., Giraud, Andrew S., Wang, Timothy C.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970811/
https://www.ncbi.nlm.nih.gov/pubmed/21209778
http://dx.doi.org/10.1007/s12307-009-0033-8
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author Worthley, Daniel L.
Giraud, Andrew S.
Wang, Timothy C.
author_facet Worthley, Daniel L.
Giraud, Andrew S.
Wang, Timothy C.
author_sort Worthley, Daniel L.
collection PubMed
description The normal gastrointestinal stroma consists of extra-cellular matrix and a community of stromal cells including fibroblasts, myofibroblasts, smooth muscle cells, pericytes, endothelium and inflammatory cells. α-smooth muscle actin (α-SMA) positive stromal fibroblasts, often referred to as myofibroblasts or activated fibroblasts, are critical in the development of digestive cancer and help to create an environment that is permissive of tumor growth, angiogenesis and invasion. This review focusses on the contribution of activated fibroblasts in carcinogenesis and where possible directly applies this to, and draws on examples from, gastrointestinal cancer. In particular, the review expands on the definition, types and origins of activated fibroblasts. It examines the molecular biology of stromal fibroblasts and their contribution to the peritumoral microenvironment and concludes by exploring some of the potential clinical applications of this exciting branch of cancer research. Understanding the origin and biology of activated fibroblasts will help in the development of an integrated epithelial-stromal sequence to cancer that will ultimately inform cancer pathogenesis, natural history and future therapeutics.
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spelling pubmed-29708112010-11-29 Stromal Fibroblasts in Digestive Cancer Worthley, Daniel L. Giraud, Andrew S. Wang, Timothy C. Cancer Microenviron Review Paper The normal gastrointestinal stroma consists of extra-cellular matrix and a community of stromal cells including fibroblasts, myofibroblasts, smooth muscle cells, pericytes, endothelium and inflammatory cells. α-smooth muscle actin (α-SMA) positive stromal fibroblasts, often referred to as myofibroblasts or activated fibroblasts, are critical in the development of digestive cancer and help to create an environment that is permissive of tumor growth, angiogenesis and invasion. This review focusses on the contribution of activated fibroblasts in carcinogenesis and where possible directly applies this to, and draws on examples from, gastrointestinal cancer. In particular, the review expands on the definition, types and origins of activated fibroblasts. It examines the molecular biology of stromal fibroblasts and their contribution to the peritumoral microenvironment and concludes by exploring some of the potential clinical applications of this exciting branch of cancer research. Understanding the origin and biology of activated fibroblasts will help in the development of an integrated epithelial-stromal sequence to cancer that will ultimately inform cancer pathogenesis, natural history and future therapeutics. Springer Netherlands 2010-02-12 /pmc/articles/PMC2970811/ /pubmed/21209778 http://dx.doi.org/10.1007/s12307-009-0033-8 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review Paper
Worthley, Daniel L.
Giraud, Andrew S.
Wang, Timothy C.
Stromal Fibroblasts in Digestive Cancer
title Stromal Fibroblasts in Digestive Cancer
title_full Stromal Fibroblasts in Digestive Cancer
title_fullStr Stromal Fibroblasts in Digestive Cancer
title_full_unstemmed Stromal Fibroblasts in Digestive Cancer
title_short Stromal Fibroblasts in Digestive Cancer
title_sort stromal fibroblasts in digestive cancer
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970811/
https://www.ncbi.nlm.nih.gov/pubmed/21209778
http://dx.doi.org/10.1007/s12307-009-0033-8
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