OCCURRENCE OF NEUROLEPRIC MALIGNANT SYNDROME ON TRIHEXPHENIDYL DISCONTINUATION

The neuroleptic malignant syndrome (NMS) commonly occurs on treatment with neuroleptics, it is also reported in patients who suddenly stop drugs like levodopa, amitriptyline and imipramine. We report a case of NMS, which occurred in a patient on lithium, haloperidol and trihexyphenidyl (THP) after s...

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Autores principales: Alexander, John P., Thomas, Ranji Mathai, Das, Arunava
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1996
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970880/
https://www.ncbi.nlm.nih.gov/pubmed/21584140
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author Alexander, John P.
Thomas, Ranji Mathai
Das, Arunava
author_facet Alexander, John P.
Thomas, Ranji Mathai
Das, Arunava
author_sort Alexander, John P.
collection PubMed
description The neuroleptic malignant syndrome (NMS) commonly occurs on treatment with neuroleptics, it is also reported in patients who suddenly stop drugs like levodopa, amitriptyline and imipramine. We report a case of NMS, which occurred in a patient on lithium, haloperidol and trihexyphenidyl (THP) after sudden discontinuation of THP. The cholinergic system, through its effect on the dopaminergic system, may play a role in the genesis of NMS. Alternatively, anticholinergic withdrawal may produce extrapyramidal symptoms (EPS), and the consequent alteration in food and fluid intake may produce electrolyte imbalance which increases the risk for NMS.
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spelling pubmed-29708802011-05-16 OCCURRENCE OF NEUROLEPRIC MALIGNANT SYNDROME ON TRIHEXPHENIDYL DISCONTINUATION Alexander, John P. Thomas, Ranji Mathai Das, Arunava Indian J Psychiatry Case Report The neuroleptic malignant syndrome (NMS) commonly occurs on treatment with neuroleptics, it is also reported in patients who suddenly stop drugs like levodopa, amitriptyline and imipramine. We report a case of NMS, which occurred in a patient on lithium, haloperidol and trihexyphenidyl (THP) after sudden discontinuation of THP. The cholinergic system, through its effect on the dopaminergic system, may play a role in the genesis of NMS. Alternatively, anticholinergic withdrawal may produce extrapyramidal symptoms (EPS), and the consequent alteration in food and fluid intake may produce electrolyte imbalance which increases the risk for NMS. Medknow Publications 1996 /pmc/articles/PMC2970880/ /pubmed/21584140 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alexander, John P.
Thomas, Ranji Mathai
Das, Arunava
OCCURRENCE OF NEUROLEPRIC MALIGNANT SYNDROME ON TRIHEXPHENIDYL DISCONTINUATION
title OCCURRENCE OF NEUROLEPRIC MALIGNANT SYNDROME ON TRIHEXPHENIDYL DISCONTINUATION
title_full OCCURRENCE OF NEUROLEPRIC MALIGNANT SYNDROME ON TRIHEXPHENIDYL DISCONTINUATION
title_fullStr OCCURRENCE OF NEUROLEPRIC MALIGNANT SYNDROME ON TRIHEXPHENIDYL DISCONTINUATION
title_full_unstemmed OCCURRENCE OF NEUROLEPRIC MALIGNANT SYNDROME ON TRIHEXPHENIDYL DISCONTINUATION
title_short OCCURRENCE OF NEUROLEPRIC MALIGNANT SYNDROME ON TRIHEXPHENIDYL DISCONTINUATION
title_sort occurrence of neurolepric malignant syndrome on trihexphenidyl discontinuation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970880/
https://www.ncbi.nlm.nih.gov/pubmed/21584140
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AT dasarunava occurrenceofneurolepricmalignantsyndromeontrihexphenidyldiscontinuation

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