First-line treatment with bortezomib rapidly stimulates both osteoblast activity and bone matrix deposition in patients with multiple myeloma, and stimulates osteoblast proliferation and differentiation in vitro

OBJECTIVES: The aim of the study was to investigate the effect of bortezomib on osteoblast proliferation and differentiation, as well as on bone matrix deposition for the first time in bisphosphonate-naïve, previously untreated patients with myeloma. METHODS: Twenty newly diagnosed patients received...

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Detalles Bibliográficos
Autores principales: Lund, Thomas, Søe, Kent, Abildgaard, Niels, Garnero, Patrick, Pedersen, Per T, Ormstrup, Tina, Delaissé, Jean-Marie, Plesner, Torben
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970902/
https://www.ncbi.nlm.nih.gov/pubmed/20528908
http://dx.doi.org/10.1111/j.1600-0609.2010.01485.x

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