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2-[3-Cyano-4-(2-methyl­prop­oxy)phen­yl]-4-methyl­thia­zole-5-carboxylic acid pyridine solvate

In the title compound, C(16)H(16)N(2)O(3)S·C(5)H(5)N, the benzene and thia­zole rings of the Febuxostat [2-(3-cyano-4-isobut­yloxy)phenyl-4-methyl-5-thia­zolecarboxylic acid] mol­ecule are almost coplanar [dihedral angle = 2.4 (1)°]. The carboxyl group is coplanar with the thia­zole ring [O—C—C—C an...

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Detalles Bibliográficos
Autores principales: Zhu, Xiong, Wang, Yue, Lu, Tao
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971045/
https://www.ncbi.nlm.nih.gov/pubmed/21578222
http://dx.doi.org/10.1107/S1600536809039002
Descripción
Sumario:In the title compound, C(16)H(16)N(2)O(3)S·C(5)H(5)N, the benzene and thia­zole rings of the Febuxostat [2-(3-cyano-4-isobut­yloxy)phenyl-4-methyl-5-thia­zolecarboxylic acid] mol­ecule are almost coplanar [dihedral angle = 2.4 (1)°]. The carboxyl group is coplanar with the thia­zole ring [O—C—C—C and O—C—C—S torsion angles of −0.7 (4) and 0.6 (3)°, respectively]. The pyridine mol­ecule of crystallization is linked to the Febuxostat mol­ecule through an O—H⋯N hydrogen bond. A weak π–π stacking inter­action is observed between the benzene ring of the Febuxostat mol­ecule and pyridine mol­ecule, with a centroid–centroid distance of 3.7530 (18) Å.