Trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate

The title compound, C(22)H(21)ClFNO(6), was synthesized by the 1,3-dipolar cyclo­addition reaction of dimethyl maleate, methyl 2-amino-2-phenyl­acetate and 2-chloro-4-fluoro­benzaldehyde. The pyrrolidine ring possesses an envelope conformation and the two benzene rings are oriented at a dihedral ang...

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Detalles Bibliográficos
Autores principales: He, Long, Chen, Lian-Mei
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971169/
https://www.ncbi.nlm.nih.gov/pubmed/21578504
http://dx.doi.org/10.1107/S1600536809044274
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author He, Long
Chen, Lian-Mei
author_facet He, Long
Chen, Lian-Mei
author_sort He, Long
collection PubMed
description The title compound, C(22)H(21)ClFNO(6), was synthesized by the 1,3-dipolar cyclo­addition reaction of dimethyl maleate, methyl 2-amino-2-phenyl­acetate and 2-chloro-4-fluoro­benzaldehyde. The pyrrolidine ring possesses an envelope conformation and the two benzene rings are oriented at a dihedral angle of 68.28 (7)°. Weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure. One methyl group is disordered over two positions with a site-occupancy ratio of 0.651 (12):0.349 (12).
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spelling pubmed-29711692010-12-30 Trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate He, Long Chen, Lian-Mei Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(22)H(21)ClFNO(6), was synthesized by the 1,3-dipolar cyclo­addition reaction of dimethyl maleate, methyl 2-amino-2-phenyl­acetate and 2-chloro-4-fluoro­benzaldehyde. The pyrrolidine ring possesses an envelope conformation and the two benzene rings are oriented at a dihedral angle of 68.28 (7)°. Weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure. One methyl group is disordered over two positions with a site-occupancy ratio of 0.651 (12):0.349 (12). International Union of Crystallography 2009-10-31 /pmc/articles/PMC2971169/ /pubmed/21578504 http://dx.doi.org/10.1107/S1600536809044274 Text en © He and Chen 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
He, Long
Chen, Lian-Mei
Trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate
title Trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate
title_full Trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate
title_fullStr Trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate
title_full_unstemmed Trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate
title_short Trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate
title_sort trimethyl 5-(2-chloro-4-fluoro­phen­yl)-2-phenyl­pyrrolidine-2,3,4-tricarboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971169/
https://www.ncbi.nlm.nih.gov/pubmed/21578504
http://dx.doi.org/10.1107/S1600536809044274
work_keys_str_mv AT helong trimethyl52chloro4fluorophenyl2phenylpyrrolidine234tricarboxylate
AT chenlianmei trimethyl52chloro4fluorophenyl2phenylpyrrolidine234tricarboxylate

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