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1-Formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one

The asymmetric unit of the title compound, C(21)H(23)NO(4), contains two crystallographically independent mol­ecules A and B. In both mol­ecules, the piperidine-4-one rings adopt a distorted twist-boat conformation. The formyl group at position 1, the methoxy­phenyl ring at position 2 and the methyl...

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Autores principales: Gayathri, P., Sakthivel, P., Ponnuswamy, S., Thiruvalluvar, A., Butcher, R. J.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971181/
https://www.ncbi.nlm.nih.gov/pubmed/21578404
http://dx.doi.org/10.1107/S1600536809042457
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author Gayathri, P.
Sakthivel, P.
Ponnuswamy, S.
Thiruvalluvar, A.
Butcher, R. J.
author_facet Gayathri, P.
Sakthivel, P.
Ponnuswamy, S.
Thiruvalluvar, A.
Butcher, R. J.
author_sort Gayathri, P.
collection PubMed
description The asymmetric unit of the title compound, C(21)H(23)NO(4), contains two crystallographically independent mol­ecules A and B. In both mol­ecules, the piperidine-4-one rings adopt a distorted twist-boat conformation. The formyl group at position 1, the methoxy­phenyl ring at position 2 and the methyl group at position 3 are attached equatorially. The meth­oxy phenyl ring at position 6 has an axial orientation. The dihedral angle between the two benzene rings is 55.27 (8)° in mol­ecule A, and 55.29 (8)° in mol­ecule B. In the crystal, the mol­ecules are linked by weak C—H⋯O inter­molecular hydrogen-bond inter­actions. In addition, weak C—H⋯π inter­molecular inter­actions involving the benzene rings at positions 6 and 2 of mol­ecule B are also found in the crystal structure.
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spelling pubmed-29711812010-12-30 1-Formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one Gayathri, P. Sakthivel, P. Ponnuswamy, S. Thiruvalluvar, A. Butcher, R. J. Acta Crystallogr Sect E Struct Rep Online Organic Papers The asymmetric unit of the title compound, C(21)H(23)NO(4), contains two crystallographically independent mol­ecules A and B. In both mol­ecules, the piperidine-4-one rings adopt a distorted twist-boat conformation. The formyl group at position 1, the methoxy­phenyl ring at position 2 and the methyl group at position 3 are attached equatorially. The meth­oxy phenyl ring at position 6 has an axial orientation. The dihedral angle between the two benzene rings is 55.27 (8)° in mol­ecule A, and 55.29 (8)° in mol­ecule B. In the crystal, the mol­ecules are linked by weak C—H⋯O inter­molecular hydrogen-bond inter­actions. In addition, weak C—H⋯π inter­molecular inter­actions involving the benzene rings at positions 6 and 2 of mol­ecule B are also found in the crystal structure. International Union of Crystallography 2009-10-23 /pmc/articles/PMC2971181/ /pubmed/21578404 http://dx.doi.org/10.1107/S1600536809042457 Text en © Gayathri et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Gayathri, P.
Sakthivel, P.
Ponnuswamy, S.
Thiruvalluvar, A.
Butcher, R. J.
1-Formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one
title 1-Formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one
title_full 1-Formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one
title_fullStr 1-Formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one
title_full_unstemmed 1-Formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one
title_short 1-Formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one
title_sort 1-formyl-r-2,c-6-bis­(4-methoxy­phen­yl)-t-3-methyl­piperidin-4-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971181/
https://www.ncbi.nlm.nih.gov/pubmed/21578404
http://dx.doi.org/10.1107/S1600536809042457
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