9-[4-Hydr­oxy-3-(hydroxy­meth­yl)but­yl]guanine monohydrate

In the mol­ecular structure of the title compound, also named penciclovir monohydrate, C(10)H(15)N(5)O(3)·H(2)O, the 4-hydr­oxy-3-hydroxy­methyl­but-1-yl group is connected to guanine through an N atom of the imidazole ring. Water mol­ecules stabilize the mol­ecular packing by forming O—H⋯O hydrogen...

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Detalles Bibliográficos
Autores principales: Tang, Huang, Cheng, Feng-Jie, Li, Nan, Liu, Yan-Cheng, Chen, Zhen-Feng
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971410/
https://www.ncbi.nlm.nih.gov/pubmed/21578464
http://dx.doi.org/10.1107/S1600536809043980
Descripción
Sumario:In the mol­ecular structure of the title compound, also named penciclovir monohydrate, C(10)H(15)N(5)O(3)·H(2)O, the 4-hydr­oxy-3-hydroxy­methyl­but-1-yl group is connected to guanine through an N atom of the imidazole ring. Water mol­ecules stabilize the mol­ecular packing by forming O—H⋯O hydrogen bonds. A three-dimensional network is generated via inter­molecular N—H⋯N, N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonding.

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