Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor

ABSTRACT: Anaplastic large T-cell lymphoma (ALCL) is frequently associated with the t(2;5)(p23;q35). Here, we report a case of ALCL with an atypical translocation of t(2;5)(p24;q13) and other complex translocations. This complex abnormal karyotype may result in chemotherapy resistance and a poor out...

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Autores principales: Wang, Lei, Tong, Yin, Chen, Zhimei, Xu, Weilai, Jin, Jie
Formato: Texto
Lenguaje:English
Publicado: Informa Healthcare 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971488/
https://www.ncbi.nlm.nih.gov/pubmed/20977317
http://dx.doi.org/10.3109/03009734.2010.500061
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author Wang, Lei
Tong, Yin
Chen, Zhimei
Xu, Weilai
Jin, Jie
author_facet Wang, Lei
Tong, Yin
Chen, Zhimei
Xu, Weilai
Jin, Jie
author_sort Wang, Lei
collection PubMed
description ABSTRACT: Anaplastic large T-cell lymphoma (ALCL) is frequently associated with the t(2;5)(p23;q35). Here, we report a case of ALCL with an atypical translocation of t(2;5)(p24;q13) and other complex translocations. This complex abnormal karyotype may result in chemotherapy resistance and a poor outcome. Interestingly, a hypophyseal tumor was detected simultaneously by magnetic resonance imaging in this case. We think it is probable that the tumor in the hypophysis might be associated with the ALCL.
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spelling pubmed-29714882010-11-08 Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor Wang, Lei Tong, Yin Chen, Zhimei Xu, Weilai Jin, Jie Ups J Med Sci Case Report ABSTRACT: Anaplastic large T-cell lymphoma (ALCL) is frequently associated with the t(2;5)(p23;q35). Here, we report a case of ALCL with an atypical translocation of t(2;5)(p24;q13) and other complex translocations. This complex abnormal karyotype may result in chemotherapy resistance and a poor outcome. Interestingly, a hypophyseal tumor was detected simultaneously by magnetic resonance imaging in this case. We think it is probable that the tumor in the hypophysis might be associated with the ALCL. Informa Healthcare 2010-10 2010-10-27 /pmc/articles/PMC2971488/ /pubmed/20977317 http://dx.doi.org/10.3109/03009734.2010.500061 Text en © Upsala Medical Society http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Case Report
Wang, Lei
Tong, Yin
Chen, Zhimei
Xu, Weilai
Jin, Jie
Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor
title Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor
title_full Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor
title_fullStr Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor
title_full_unstemmed Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor
title_short Anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor
title_sort anaplastic large-cell lymphoma with atypical chromosomal translocation t(2;5) and hypophyseal tumor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971488/
https://www.ncbi.nlm.nih.gov/pubmed/20977317
http://dx.doi.org/10.3109/03009734.2010.500061
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AT tongyin anaplasticlargecelllymphomawithatypicalchromosomaltranslocationt25andhypophysealtumor
AT chenzhimei anaplasticlargecelllymphomawithatypicalchromosomaltranslocationt25andhypophysealtumor
AT xuweilai anaplasticlargecelllymphomawithatypicalchromosomaltranslocationt25andhypophysealtumor
AT jinjie anaplasticlargecelllymphomawithatypicalchromosomaltranslocationt25andhypophysealtumor

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