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Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime
The employment of 3-pyridine aldoxime, (3-py)CHNOH, in Zn(II) chemistry has afforded two novel compounds: [Zn(acac)(2){(3-py)CHNOH}]·H(2)O (1·H(2)O) [where acac(−) is the pentane-2,4-dionato(-1) ion] and [Zn(2)(O(2)CMe)(4){(3-py)CHNOH}(2)] (2). Complex 1·H(2)O crystallizes in the monoclinic space gr...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971566/ https://www.ncbi.nlm.nih.gov/pubmed/21076521 http://dx.doi.org/10.1155/2010/803424 |
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author | Konidaris, Konstantis F. Papi, Rigini Katsoulakou, Eugenia Raptopoulou, Catherine P. Kyriakidis, Dimitrios A. Manessi-Zoupa, Evy |
author_facet | Konidaris, Konstantis F. Papi, Rigini Katsoulakou, Eugenia Raptopoulou, Catherine P. Kyriakidis, Dimitrios A. Manessi-Zoupa, Evy |
author_sort | Konidaris, Konstantis F. |
collection | PubMed |
description | The employment of 3-pyridine aldoxime, (3-py)CHNOH, in Zn(II) chemistry has afforded two novel compounds: [Zn(acac)(2){(3-py)CHNOH}]·H(2)O (1·H(2)O) [where acac(−) is the pentane-2,4-dionato(-1) ion] and [Zn(2)(O(2)CMe)(4){(3-py)CHNOH}(2)] (2). Complex 1·H(2)O crystallizes in the monoclinic space group P2(1)/n. The Zn(II) ion is five-coordinated, surrounded by four oxygen atoms of two acac(−) moieties and by the pyridyl nitrogen atom of the (3-py)CHNOH ligand. Molecules of 1 interact with the water lattice molecules forming a 2D hydrogen-bonding network. Complex 2 crystallizes in the triclinic P-1 space group and displays a dinuclear paddle-wheel structure. Each Zn(II) exhibits a perfect square pyramidal geometry, with four carboxylate oxygen atoms at the basal plane and the pyridyl nitrogen of one monodentate (3-py)CHNOH ligand at the apex. DNA mobility shift assays were performed for the determination of the in vitro effect of both complexes on the integrity and the electrophoretic mobility of pDNA. |
format | Text |
id | pubmed-2971566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29715662010-11-12 Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime Konidaris, Konstantis F. Papi, Rigini Katsoulakou, Eugenia Raptopoulou, Catherine P. Kyriakidis, Dimitrios A. Manessi-Zoupa, Evy Bioinorg Chem Appl Research Article The employment of 3-pyridine aldoxime, (3-py)CHNOH, in Zn(II) chemistry has afforded two novel compounds: [Zn(acac)(2){(3-py)CHNOH}]·H(2)O (1·H(2)O) [where acac(−) is the pentane-2,4-dionato(-1) ion] and [Zn(2)(O(2)CMe)(4){(3-py)CHNOH}(2)] (2). Complex 1·H(2)O crystallizes in the monoclinic space group P2(1)/n. The Zn(II) ion is five-coordinated, surrounded by four oxygen atoms of two acac(−) moieties and by the pyridyl nitrogen atom of the (3-py)CHNOH ligand. Molecules of 1 interact with the water lattice molecules forming a 2D hydrogen-bonding network. Complex 2 crystallizes in the triclinic P-1 space group and displays a dinuclear paddle-wheel structure. Each Zn(II) exhibits a perfect square pyramidal geometry, with four carboxylate oxygen atoms at the basal plane and the pyridyl nitrogen of one monodentate (3-py)CHNOH ligand at the apex. DNA mobility shift assays were performed for the determination of the in vitro effect of both complexes on the integrity and the electrophoretic mobility of pDNA. Hindawi Publishing Corporation 2010 2010-11-02 /pmc/articles/PMC2971566/ /pubmed/21076521 http://dx.doi.org/10.1155/2010/803424 Text en Copyright © 2010 Konstantis F. Konidaris et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Konidaris, Konstantis F. Papi, Rigini Katsoulakou, Eugenia Raptopoulou, Catherine P. Kyriakidis, Dimitrios A. Manessi-Zoupa, Evy Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
title | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
title_full | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
title_fullStr | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
title_full_unstemmed | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
title_short | Synthesis, Crystal Structures, and DNA Binding Properties of Zinc(II) Complexes with 3-Pyridine Aldoxime |
title_sort | synthesis, crystal structures, and dna binding properties of zinc(ii) complexes with 3-pyridine aldoxime |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971566/ https://www.ncbi.nlm.nih.gov/pubmed/21076521 http://dx.doi.org/10.1155/2010/803424 |
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