SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks

Summary: SpotXplore is a plugin for Cytoscape for extraction and visualization of differentially expressed subnetworks (hotspots) from gene networks. The hotspot-based visualization approach enables interactive exploration of regulatory interactions in differentially expressed gene sets, and it allows a researcher to explore gene expression in direct relation to the affected cellular gene network. The hotspots provide a view beyond the commonly used metabolic pathways and gene ontologies. Availability: http://www.win.tue.nl/∼mwestenb/spotxplore/ Contact: m.a.westenberg@tue.nl Supplementary information: Example data and user manual are available at SpotXplore's web site.