Cargando…

The role of progesterone in prevention of preterm birth

Preterm birth continues to provide an enormous challenge in the delivery of perinatal health care, and is associated with considerable short and long-term health consequences for surviving infants. Progesterone has a role in maintaining pregnancy, by suppression of the calcium–calmodulin–myosin ligh...

Descripción completa

Detalles Bibliográficos
Autores principales: Dodd, Jodie M, Crowther, Caroline A
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971700/
https://www.ncbi.nlm.nih.gov/pubmed/21072277
_version_ 1782190647454728192
author Dodd, Jodie M
Crowther, Caroline A
author_facet Dodd, Jodie M
Crowther, Caroline A
author_sort Dodd, Jodie M
collection PubMed
description Preterm birth continues to provide an enormous challenge in the delivery of perinatal health care, and is associated with considerable short and long-term health consequences for surviving infants. Progesterone has a role in maintaining pregnancy, by suppression of the calcium–calmodulin–myosin light chain kinase system. Additionally, progesterone has recognized anti-inflammatory properties, raising a possible link between inflammatory processes, alterations in progesterone receptor expression and the onset of preterm labor. Systematic reviews of randomized controlled trials evaluating the use of intramuscular and vaginal progesterone in women considered to be at increased risk of preterm birth have been published, with primary outcomes of perinatal death, preterm birth <34 weeks, and neurodevelopmental handicap in childhood. Eleven randomized controlled trials were included in the systematic review, involving 2714 women and 3452 infants, with results presented according to the reason women were considered to be at increased risk of preterm birth. While there is a potential beneficial effect in the use of progesterone for some women considered to be at increased risk of preterm birth, primarily in the reduction in the risk of preterm birth before 34 weeks gestation, it remains unclear if the observed prolongation of pregnancy translates into improved health outcomes for the infant.
format Text
id pubmed-2971700
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-29717002010-11-10 The role of progesterone in prevention of preterm birth Dodd, Jodie M Crowther, Caroline A Int J Womens Health Review Preterm birth continues to provide an enormous challenge in the delivery of perinatal health care, and is associated with considerable short and long-term health consequences for surviving infants. Progesterone has a role in maintaining pregnancy, by suppression of the calcium–calmodulin–myosin light chain kinase system. Additionally, progesterone has recognized anti-inflammatory properties, raising a possible link between inflammatory processes, alterations in progesterone receptor expression and the onset of preterm labor. Systematic reviews of randomized controlled trials evaluating the use of intramuscular and vaginal progesterone in women considered to be at increased risk of preterm birth have been published, with primary outcomes of perinatal death, preterm birth <34 weeks, and neurodevelopmental handicap in childhood. Eleven randomized controlled trials were included in the systematic review, involving 2714 women and 3452 infants, with results presented according to the reason women were considered to be at increased risk of preterm birth. While there is a potential beneficial effect in the use of progesterone for some women considered to be at increased risk of preterm birth, primarily in the reduction in the risk of preterm birth before 34 weeks gestation, it remains unclear if the observed prolongation of pregnancy translates into improved health outcomes for the infant. Dove Medical Press 2010-08-09 /pmc/articles/PMC2971700/ /pubmed/21072277 Text en © 2009 Dodd and Crowther, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Dodd, Jodie M
Crowther, Caroline A
The role of progesterone in prevention of preterm birth
title The role of progesterone in prevention of preterm birth
title_full The role of progesterone in prevention of preterm birth
title_fullStr The role of progesterone in prevention of preterm birth
title_full_unstemmed The role of progesterone in prevention of preterm birth
title_short The role of progesterone in prevention of preterm birth
title_sort role of progesterone in prevention of preterm birth
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971700/
https://www.ncbi.nlm.nih.gov/pubmed/21072277
work_keys_str_mv AT doddjodiem theroleofprogesteroneinpreventionofpretermbirth
AT crowthercarolinea theroleofprogesteroneinpreventionofpretermbirth
AT doddjodiem roleofprogesteroneinpreventionofpretermbirth
AT crowthercarolinea roleofprogesteroneinpreventionofpretermbirth