Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)

In the crystal of the title mol­ecular salt, C(19)H(24)N(3)O(+)·C(14)H(13)N(8)O(4)S(3) (−), the cations and anions are linked by N—H⋯O hydrogen bonds. Short intra­molecular C—H⋯O contacts occur within the anion and inter­molecular C—H⋯O and C—H⋯π bonds help to establish the packing....

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Detalles Bibliográficos
Autores principales: Asghar, Amina, Iqbal, Mohammad S., Tahir, M. Nawaz
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971840/
https://www.ncbi.nlm.nih.gov/pubmed/21578855
http://dx.doi.org/10.1107/S1600536809047941
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author Asghar, Amina
Iqbal, Mohammad S.
Tahir, M. Nawaz
author_facet Asghar, Amina
Iqbal, Mohammad S.
Tahir, M. Nawaz
author_sort Asghar, Amina
collection PubMed
description In the crystal of the title mol­ecular salt, C(19)H(24)N(3)O(+)·C(14)H(13)N(8)O(4)S(3) (−), the cations and anions are linked by N—H⋯O hydrogen bonds. Short intra­molecular C—H⋯O contacts occur within the anion and inter­molecular C—H⋯O and C—H⋯π bonds help to establish the packing.
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spelling pubmed-29718402010-12-30 Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate) Asghar, Amina Iqbal, Mohammad S. Tahir, M. Nawaz Acta Crystallogr Sect E Struct Rep Online Organic Papers In the crystal of the title mol­ecular salt, C(19)H(24)N(3)O(+)·C(14)H(13)N(8)O(4)S(3) (−), the cations and anions are linked by N—H⋯O hydrogen bonds. Short intra­molecular C—H⋯O contacts occur within the anion and inter­molecular C—H⋯O and C—H⋯π bonds help to establish the packing. International Union of Crystallography 2009-11-21 /pmc/articles/PMC2971840/ /pubmed/21578855 http://dx.doi.org/10.1107/S1600536809047941 Text en © Asghar et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Asghar, Amina
Iqbal, Mohammad S.
Tahir, M. Nawaz
Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)
title Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)
title_full Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)
title_fullStr Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)
title_full_unstemmed Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)
title_short Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)
title_sort mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1h-indazol-3-yl)­oxy]-n,n-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1h-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971840/
https://www.ncbi.nlm.nih.gov/pubmed/21578855
http://dx.doi.org/10.1107/S1600536809047941
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