Lactic Acid Induces Aberrant Amyloid Precursor Protein Processing by Promoting Its Interaction with Endoplasmic Reticulum Chaperone Proteins

BACKGROUND: Lactic acid, a natural by-product of glycolysis, is produced at excess levels in response to impaired mitochondrial function, high-energy demand, and low oxygen availability. The enzyme involved in the production of β-amyloid peptide (Aβ) of Alzheimer's disease, BACE1, functions opt...

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Detalles Bibliográficos
Autores principales: Xiang, Yiwen, Xu, Guilian, Weigel-Van Aken, Kirsten A. K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972223/
https://www.ncbi.nlm.nih.gov/pubmed/21072203
http://dx.doi.org/10.1371/journal.pone.0013820

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