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Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line

Butyrate, a known histone deacetylase inhibitor (HDACi) and product of fibre fermentation, is postulated to mediate the protective effect of dietary fibre against colon cancer. The transcription factor Sp1 is a target of acetylation and is known to be associated with class I HDACs, including HDAC1....

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Detalles Bibliográficos
Autores principales:	Waby, Jennifer S, Chirakkal, Haridasan, Yu, ChenWei, Griffiths, Gareth J, Benson, Roderick SP, Bingle, Colin D, Corfe, Bernard M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972244/ https://www.ncbi.nlm.nih.gov/pubmed/20950428 http://dx.doi.org/10.1186/1476-4598-9-275

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