Cargando…

ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus

BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of d...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Dae Joon, Lee, Dong Gyu, Kim, Hee-Jung, Cho, Eun Hee, Kim, Sang-Wook
Formato: Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972492/
https://www.ncbi.nlm.nih.gov/pubmed/21076580
http://dx.doi.org/10.4093/kdj.2010.34.5.320
_version_ 1782190804973912064
author Jeong, Dae Joon
Lee, Dong Gyu
Kim, Hee-Jung
Cho, Eun Hee
Kim, Sang-Wook
author_facet Jeong, Dae Joon
Lee, Dong Gyu
Kim, Hee-Jung
Cho, Eun Hee
Kim, Sang-Wook
author_sort Jeong, Dae Joon
collection PubMed
description BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients. METHODS: The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified. RESULTS: The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959). CONCLUSIONS: The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.
format Text
id pubmed-2972492
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Korean Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-29724922010-11-12 ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus Jeong, Dae Joon Lee, Dong Gyu Kim, Hee-Jung Cho, Eun Hee Kim, Sang-Wook Korean Diabetes J Original Article BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients. METHODS: The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified. RESULTS: The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959). CONCLUSIONS: The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM. Korean Diabetes Association 2010-10 2010-10-31 /pmc/articles/PMC2972492/ /pubmed/21076580 http://dx.doi.org/10.4093/kdj.2010.34.5.320 Text en Copyright © 2010 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jeong, Dae Joon
Lee, Dong Gyu
Kim, Hee-Jung
Cho, Eun Hee
Kim, Sang-Wook
ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
title ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
title_full ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
title_fullStr ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
title_full_unstemmed ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
title_short ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
title_sort enpp1 k121q genotype not associated with coronary artery calcification in korean patients with type 2 diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972492/
https://www.ncbi.nlm.nih.gov/pubmed/21076580
http://dx.doi.org/10.4093/kdj.2010.34.5.320
work_keys_str_mv AT jeongdaejoon enpp1k121qgenotypenotassociatedwithcoronaryarterycalcificationinkoreanpatientswithtype2diabetesmellitus
AT leedonggyu enpp1k121qgenotypenotassociatedwithcoronaryarterycalcificationinkoreanpatientswithtype2diabetesmellitus
AT kimheejung enpp1k121qgenotypenotassociatedwithcoronaryarterycalcificationinkoreanpatientswithtype2diabetesmellitus
AT choeunhee enpp1k121qgenotypenotassociatedwithcoronaryarterycalcificationinkoreanpatientswithtype2diabetesmellitus
AT kimsangwook enpp1k121qgenotypenotassociatedwithcoronaryarterycalcificationinkoreanpatientswithtype2diabetesmellitus