Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice

INTRODUCTION: We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae). METHODS: We used elevated plus maze, spontaneous motor activity and ketamine‐induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty c...

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Autores principales: Hajhashemi, Valiollah, Rabbani, Mohammad, Ghanadi, Alireza, Davari, Elahe
Formato: Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2010
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972602/
https://www.ncbi.nlm.nih.gov/pubmed/21120308
http://dx.doi.org/10.1590/S1807-59322010001000020
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author Hajhashemi, Valiollah
Rabbani, Mohammad
Ghanadi, Alireza
Davari, Elahe
author_facet Hajhashemi, Valiollah
Rabbani, Mohammad
Ghanadi, Alireza
Davari, Elahe
author_sort Hajhashemi, Valiollah
collection PubMed
description INTRODUCTION: We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae). METHODS: We used elevated plus maze, spontaneous motor activity and ketamine‐induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n‐decanal (70.1%) and alpha‐pinene (12.4%) constituted the major components. RESULTS: In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25–200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine‐induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect.
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spelling pubmed-29726022010-11-04 Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice Hajhashemi, Valiollah Rabbani, Mohammad Ghanadi, Alireza Davari, Elahe Clinics (Sao Paulo) Basic Research INTRODUCTION: We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae). METHODS: We used elevated plus maze, spontaneous motor activity and ketamine‐induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n‐decanal (70.1%) and alpha‐pinene (12.4%) constituted the major components. RESULTS: In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25–200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine‐induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2010-10 /pmc/articles/PMC2972602/ /pubmed/21120308 http://dx.doi.org/10.1590/S1807-59322010001000020 Text en Copyright © 2010 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Research
Hajhashemi, Valiollah
Rabbani, Mohammad
Ghanadi, Alireza
Davari, Elahe
Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_full Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_fullStr Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_full_unstemmed Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_short Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_sort evaluation of antianxiety and sedative effects of essential oil of ducrosia anethifolia in mice
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972602/
https://www.ncbi.nlm.nih.gov/pubmed/21120308
http://dx.doi.org/10.1590/S1807-59322010001000020
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