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Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart
Heart formation requires a highly balanced network of transcriptional activation of genes. The homeodomain transcription factor, Shox2, is essential for the formation of the sinoatrial valves and for the development of the pacemaking system. The elucidation of molecular mechanisms underlying the dev...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972695/ https://www.ncbi.nlm.nih.gov/pubmed/20858598 http://dx.doi.org/10.1093/hmg/ddq393 |