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AP1 Factor Inactivation in the Suprabasal Epidermis Causes Increased Epidermal Hyperproliferation and Hyperkeratosis but Reduced Carcinogen-Dependent Tumor Formation
AP1 (jun/fos) factors comprise a family of transcriptional regulators (c-jun, junB, junD, c-fos, FosB, Fra-1 and Fra-2) that are key controllers of epidermal keratinocyte survival and differentiation, and are important drivers of cancer development. Understanding the role of these factors in epiderm...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974027/ https://www.ncbi.nlm.nih.gov/pubmed/20818430 http://dx.doi.org/10.1038/onc.2010.315 |