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Novel Approaches to Inhibition of Gastric Acid Secretion
The gastric H,K-adenosine triphosphatase (ATPase) is the primary target for treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0 that allows selective accumulation in the secretory canalicu...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Current Science Inc.
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974194/ https://www.ncbi.nlm.nih.gov/pubmed/20924727 http://dx.doi.org/10.1007/s11894-010-0149-5 |