Aquaporin 1, a potential therapeutic target for migraine with aura

The pathophysiology of migraine remains largely unknown. However, evidence regarding the molecules participating in the pathophysiology of migraine has been accumulating. Water channel proteins, known as aquaporins (AQPs), notably AQP-1 and AQP-4, appears to be involved in the pathophysiology of sev...

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Detalles Bibliográficos
Autores principales: Xu, Guang-Yin, Wang, Fen, Jiang, Xinghong, Tao, Jin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974658/
https://www.ncbi.nlm.nih.gov/pubmed/20969805
http://dx.doi.org/10.1186/1744-8069-6-68
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author Xu, Guang-Yin
Wang, Fen
Jiang, Xinghong
Tao, Jin
author_facet Xu, Guang-Yin
Wang, Fen
Jiang, Xinghong
Tao, Jin
author_sort Xu, Guang-Yin
collection PubMed
description The pathophysiology of migraine remains largely unknown. However, evidence regarding the molecules participating in the pathophysiology of migraine has been accumulating. Water channel proteins, known as aquaporins (AQPs), notably AQP-1 and AQP-4, appears to be involved in the pathophysiology of several neurological diseases. This review outlines newly emerging evidence indicating that AQP-1 plays an important role in pain signal transduction and migraine and could therefore serve as a potential therapeutic target for these diseases.
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spelling pubmed-29746582010-11-06 Aquaporin 1, a potential therapeutic target for migraine with aura Xu, Guang-Yin Wang, Fen Jiang, Xinghong Tao, Jin Mol Pain Review The pathophysiology of migraine remains largely unknown. However, evidence regarding the molecules participating in the pathophysiology of migraine has been accumulating. Water channel proteins, known as aquaporins (AQPs), notably AQP-1 and AQP-4, appears to be involved in the pathophysiology of several neurological diseases. This review outlines newly emerging evidence indicating that AQP-1 plays an important role in pain signal transduction and migraine and could therefore serve as a potential therapeutic target for these diseases. BioMed Central 2010-10-25 /pmc/articles/PMC2974658/ /pubmed/20969805 http://dx.doi.org/10.1186/1744-8069-6-68 Text en Copyright ©2010 Xu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Xu, Guang-Yin
Wang, Fen
Jiang, Xinghong
Tao, Jin
Aquaporin 1, a potential therapeutic target for migraine with aura
title Aquaporin 1, a potential therapeutic target for migraine with aura
title_full Aquaporin 1, a potential therapeutic target for migraine with aura
title_fullStr Aquaporin 1, a potential therapeutic target for migraine with aura
title_full_unstemmed Aquaporin 1, a potential therapeutic target for migraine with aura
title_short Aquaporin 1, a potential therapeutic target for migraine with aura
title_sort aquaporin 1, a potential therapeutic target for migraine with aura
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974658/
https://www.ncbi.nlm.nih.gov/pubmed/20969805
http://dx.doi.org/10.1186/1744-8069-6-68
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AT wangfen aquaporin1apotentialtherapeutictargetformigrainewithaura
AT jiangxinghong aquaporin1apotentialtherapeutictargetformigrainewithaura
AT taojin aquaporin1apotentialtherapeutictargetformigrainewithaura

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